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Literature DB >> 3229897

Liposome-bound cyclosporine: aqueous and vitreous level after subconjunctival injection.

A A Alghadyan¹, G A Peyman, B Khoobehi, S Milner, K R Liu.

Abstract

The concentration of cyclosporine in the aqueous and vitreous humors of albino rabbits was measured, using HPLC at intervals of 24, 48, 96, and 192 hours after subconjunctival injections of 2.5 mg of free or liposome-bound cyclosporine. The aqueous concentration was reasonably high in both groups until day 4: 1050 nanograms per milliliter in the group receiving free cyclosporine, and 1438 nanograms per milliliter in the group receiving liposome-bound cyclosporine. The vitreous concentration was very low in both groups.

Entities: Chemical Species

Mesh：

Substances：

Year: 1988 PMID： 3229897 DOI： 10.1007/bf00137133

Source DB: PubMed Journal: Int Ophthalmol ISSN： 0165-5701 Impact factor: 2.031

15 in total

1. Biological effects of cyclosporin A: a new antilymphocytic agent.

Authors: J F Borel; C Feurer; H U Gubler; H Stähelin
Journal: Agents Actions Date: 1976-07

2. Dissecting ocular tissue for intraocular drug studies.

Authors: R Abel; G L Boyle
Journal: Invest Ophthalmol Date: 1976-03

3. Prolonged survival of corneal allografts in rabbits treated with cyclosporin A.

Authors: D J Coster; W F Shepherd; T C Fook; N S Rice; B R Jones
Journal: Lancet Date: 1979-09-29 Impact factor: 79.321

4. Local cyclosporine therapy for experimental autoimmune uveitis in rats.

Authors: R B Nussenblatt; W J Dinning; L S Fujikawa; C C Chan; A G Palestine
Journal: Arch Ophthalmol Date: 1985-10

5. A placebo-controlled blind trial of cyclosporin-A in prevention of corneal graft rejection in rabbits.

Authors: T A Bell; D L Easty; K G McCullagh
Journal: Br J Ophthalmol Date: 1982-05 Impact factor: 4.638

6. Cyclosporin A: tissue levels following topical and systemic administration to rabbits.

Authors: T A Bell; A G Hunnisett
Journal: Br J Ophthalmol Date: 1986-11 Impact factor: 4.638

7. Suppression of corneal allograft rejection by cyclosporin A.

Authors: J D Salisbury; B M Gebhardt
Journal: Arch Ophthalmol Date: 1981-09

8. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

Authors: F Szoka; D Papahadjopoulos
Journal: Proc Natl Acad Sci U S A Date: 1978-09 Impact factor: 11.205

Liposome-bound cyclosporine: aqueous and vitreous level after subconjunctival injection.

1. Biological effects of cyclosporin A: a new antilymphocytic agent.

2. Dissecting ocular tissue for intraocular drug studies.

3. Prolonged survival of corneal allografts in rabbits treated with cyclosporin A.

4. Local cyclosporine therapy for experimental autoimmune uveitis in rats.

5. A placebo-controlled blind trial of cyclosporin-A in prevention of corneal graft rejection in rabbits.

6. Cyclosporin A: tissue levels following topical and systemic administration to rabbits.

7. Suppression of corneal allograft rejection by cyclosporin A.

8. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

9. Pharmacokinetic of topical cyclosporin A in the rabbit eye.

10. Cyclosporin A applied topically to the recipient eye inhibits corneal graft rejection.

1. Liposome-bound cyclosporine: clearance after intravitreal injection.

2. Diabetic retinopathy - An update.

Review 3. An overview on dry eye treatment: approaches for cyclosporin a delivery.