| Literature DB >> 77948 |
R Y Calne, D J White, K Rolles, D P Smith, B M Herbertson.
Abstract
Cyclosporin A was given to pigs receiving orthotopic cardiac allografts from donors mismatched at the major locus. Median survival in 20 control pigs was only 6 days; in 5 pigs given cyclosporin A at 15 mg/kg on 3 days median survival was 22 days; and when 6 animals were given 25 mg/kg intramuscularly for 2 days and then orally median survival is greater than 68 days, with 4 animals still alive.Entities:
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Year: 1978 PMID： 77948 DOI： 10.1016/s0140-6736(78)90971-6
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321