Literature DB >> 3792847

The effect of topical cyclosporin A on the rabbit cornea. A clinical and electron microscopic study.

W Behrens-Baumann, S Theuring, H Brewitt.   

Abstract

To investigate the effect of topical cyclosporin A (CSA) on the rabbit cornea, both eyes of 80 animals were treated with CSA 2% eye drops over a 3-week period under various conditions. CSA was dissolved in castor oil or ethanol 13.8 vol. %. Slit-lamp, scanning and transmission electron microscopic examinations were performed. CSA 2% in castor oil given 5 times daily showed no damage to either the corneal epithelium or endothelium. In contrast the solutions containing ethanol revealed considerable epithelial cell damage.

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Year:  1986        PMID： 3792847     DOI： 10.1007/bf02154739

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN： 0721-832X            Impact factor:   3.117


  15 in total

1.  Prolonged survival of corneal allografts in rabbits treated with cyclosporin A.

Authors:  D J Coster; W F Shepherd; T C Fook; N S Rice; B R Jones
Journal:  Lancet       Date:  1979-09-29       Impact factor: 79.321

2.  Prolonged corneal graft survival using topically applied cyclosporin A.

Authors:  P A Hunter; N S Rice; B R Jones
Journal:  Trans Ophthalmol Soc U K       Date:  1982-04

3.  A placebo-controlled blind trial of cyclosporin-A in prevention of corneal graft rejection in rabbits.

Authors:  T A Bell; D L Easty; K G McCullagh
Journal:  Br J Ophthalmol       Date:  1982-05       Impact factor: 4.638

4.  Corneal graft rejection: a new rabbit model and cyclosporin-A.

Authors:  P A Hunter; A Garner; K R Wilhelmus; N S Rice; B R Jones
Journal:  Br J Ophthalmol       Date:  1982-05       Impact factor: 4.638

5.  Early morphological changes of the corneal epithelium after burning with hydrochloric acid. A scanning electron microscope study.

Authors:  H Brewitt; H Honegger
Journal:  Ophthalmologica       Date:  1979       Impact factor: 3.250

6.  Suppression of corneal allograft rejection by cyclosporin A.

Authors:  J D Salisbury; B M Gebhardt
Journal:  Arch Ophthalmol       Date:  1981-09

7.  Ciclosporin concentration in the rabbit aqueous humor and cornea following subconjunctival administration. Importance of anatomical site of injection.

Authors:  W Behrens-Baumann; S Theuring; B Frey; F Frey; H Sostmann; J Bircher
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1986       Impact factor: 3.117

8.  Cyclosporin A applied topically to the recipient eye inhibits corneal graft rejection.

Authors:  P A Hunter; K R Wilhelmus; N S Rice; B R Jones
Journal:  Clin Exp Immunol       Date:  1981-07       Impact factor: 4.330

9.  Effect of cyclosporin A on the survival of corneal grafts in rabbits.

Authors:  W F Shepherd; D J Coster; T C Fook; N S Rice; B R Jones
Journal:  Br J Ophthalmol       Date:  1980-03       Impact factor: 4.638

10.  Potential role of cyclosporin A in corneal grafting.

Authors:  P A Hunter
Journal:  J R Soc Med       Date:  1981-11       Impact factor: 18.000
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  2 in total

1.  Topical cyclosporin stimulates neovascularization in resolving sterile rheumatoid central corneal ulcers.

Authors:  J D Gottsch; E K Akpek
Journal:  Trans Am Ophthalmol Soc       Date:  2000

2.  Physicochemical Stability of a Novel Tacrolimus Ophthalmic Formulation for the Treatment of Ophthalmic Inflammatory Diseases.

Authors:  Marion Barrieu; Philip Chennell; Mouloud Yessaad; Yassine Bouattour; Mathieu Wasiak; Mireille Jouannet; Yoann Le Basle; Valérie Sautou
Journal:  Pharmaceutics       Date:  2022-01-04       Impact factor: 6.321
  2 in total

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