Literature DB >> 7018898

Prevention of endotoxin-induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony.

J N Moore, H E Garner, J E Shapland, D G Hatfield.   

Abstract

Bacterial endotoxin injected intravenously into conscious ponies produced alterations in cardiopulmonary and gastrointestinal function. Specifically, tachypnoea, dyspnoea, hypoxaemia, colic, lactic acidosis and diarrhoea resulted from administration of 10 micrograms/kg Escherichia coli endotoxin. Pretreatment of the ponies with a potent prostaglandin synthetase inhibitor, flunixin meglumine, prevented these ill effects of endotoxin.

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Year:  1981        PMID： 7018898     DOI： 10.1111/j.2042-3306.1981.tb04122.x

Source DB:  PubMed          Journal:  Equine Vet J        ISSN： 0425-1644            Impact factor:   2.888


  10 in total

1.  Clinical and pathological effects of flunixin meglumine administration to neonatal foals.

Authors:  J B Carrick; M G Papich; D M Middleton; J M Naylor; H G Townsend
Journal:  Can J Vet Res       Date:  1989-04       Impact factor: 1.310

2.  Some reproductive and clinical aspects of endotoxins in cows with special emphasis on the role of prostaglandins.

Authors:  G Fredriksson
Journal:  Acta Vet Scand       Date:  1984       Impact factor: 1.695

3.  Yohimbine ameliorates the effects of endotoxin on gastric emptying of the liquid marker acetaminophen in horses.

Authors:  S D Meisler; T J Doherty; F M Andrews; D Osborne; D L Frazier
Journal:  Can J Vet Res       Date:  2000-10       Impact factor: 1.310

4.  Some endotoxin-induced clinical and biochemical changes in plasma of camels (Camelus dromedarius).

Authors:  A M Al-Dughaym
Journal:  Vet Res Commun       Date:  2004-11       Impact factor: 2.459

5.  Evaluation of the brain, renal, and hepatic effects of flunixin meglumine, ketoprofen, and phenylbutazone administration in Iranian fat-tailed sheep.

Authors:  Ali Asghar Mozaffari; Amin Derakhshanfar
Journal:  Trop Anim Health Prod       Date:  2011-04-19       Impact factor: 1.559

6.  Sparing the gut: COX-2 inhibitors herald a new era for treatment of horses with surgical colic.

Authors:  A L Ziegler; A T Blikslager
Journal:  Equine Vet Educ       Date:  2019-10-04       Impact factor: 1.063

7.  Accuracy of pulse oximetry and capnography in healthy and compromised horses during spontaneous and controlled ventilation.

Authors:  Judith Koenig; Wayne McDonell; Alexander Valverde
Journal:  Can J Vet Res       Date:  2003-07       Impact factor: 1.310

8.  Phenylbutazone prevents the endotoxin-induced delay in gastric emptying in horses.

Authors:  N Valk; T J Doherty; J T Blackford; T W Abraha; D L Frazier
Journal:  Can J Vet Res       Date:  1998-07       Impact factor: 1.310

9.  Metoclopramide ameliorates the effects of endotoxin on gastric emptying of acetaminophen in horses.

Authors:  T J Doherty; F M Andrews; T W Abraha; D Osborne; D L Frazier
Journal:  Can J Vet Res       Date:  1999-01       Impact factor: 1.310

10.  Comparison of the effects of ketoprofen and flunixin meglumine on the in vitro response of equine peripheral blood monocytes to bacterial endotoxin.

Authors:  B R Jackman; J N Moore; M H Barton; D D Morris
Journal:  Can J Vet Res       Date:  1994-04       Impact factor: 1.310
  10 in total

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