Literature DB >> 9918332

Metoclopramide ameliorates the effects of endotoxin on gastric emptying of acetaminophen in horses.

T J Doherty1, F M Andrews, T W Abraha, D Osborne, D L Frazier.   

Abstract

The effect of metoclopramide on gastric emptying of a liquid marker in horses was evaluated by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal, fasted horses (n = 7), horses given endotoxin intravenously (n = 7), and horses given intravenous metoclopramide plus endotoxin (n = 6). The mean time to reach maximum serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration vs time curve (AUC) were compared among treatment groups. Endotoxin caused a profound delay in gastric emptying, and pretreatment with metoclopramide significantly (P < 0.05) ameliorated this effect.

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Year:  1999        PMID： 9918332      PMCID： PMC1189513     

Source DB:  PubMed          Journal:  Can J Vet Res        ISSN： 0830-9000            Impact factor:   1.310


  15 in total

1.  Altered absorption of digoxin in patients given propantheline and metoclopramide.

Authors:  V Manninen; A Apajalahti; J Melin; M Karesoja
Journal:  Lancet       Date:  1973-02-24       Impact factor: 79.321

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Journal:  Clin Pharmacol Ther       Date:  1978-10       Impact factor: 6.875

3.  Prevention of endotoxin-induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony.

Authors:  J N Moore; H E Garner; J E Shapland; D G Hatfield
Journal:  Equine Vet J       Date:  1981-04       Impact factor: 2.888

4.  The action of low dose endotoxin on equine bowel motility.

Authors:  J N King; E L Gerring
Journal:  Equine Vet J       Date:  1991-01       Impact factor: 2.888

Review 5.  Therapeutic potential of drugs with mixed 5-HT4 agonist/5-HT3 antagonist action in the control of emesis.

Authors:  M Tonini; S M Candura; E Messori; C A Rizzi
Journal:  Pharmacol Res       Date:  1995-05       Impact factor: 7.658

6.  Blockade of endotoxin-induced cecal hypoperfusion and ileus with an alpha 2 antagonist in horses.

Authors:  S C Eades; J N Moore
Journal:  Am J Vet Res       Date:  1993-04       Impact factor: 1.156

7.  Detection of endotoxin in cases of equine colic.

Authors:  J N King; E L Gerring
Journal:  Vet Rec       Date:  1988-09-03       Impact factor: 2.695

8.  Effect of vasopressors on organ blood flow during endotoxin shock in pigs.

Authors:  M J Breslow; C F Miller; S D Parker; A T Walman; R J Traystman
Journal:  Am J Physiol       Date:  1987-02

9.  Effects of meals on gastric emptying and small intestinal transit times of a suspension in the beagle dog assessed using acetaminophen and salicylazosulfapyridine as markers.

Authors:  H Mizuta; Y Kawazoe; K Haga; K Ogawa
Journal:  Chem Pharm Bull (Tokyo)       Date:  1990-08       Impact factor: 1.645

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Authors:  E E Gerring; J M Hunt
Journal:  Equine Vet J       Date:  1986-07       Impact factor: 2.888
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  2 in total

Review 1.  Equine gastrointestinal motility--ileus and pharmacological modification.

Authors:  Judith Koenig; Nathalie Cote
Journal:  Can Vet J       Date:  2006-06       Impact factor: 1.008

2.  Yohimbine ameliorates the effects of endotoxin on gastric emptying of the liquid marker acetaminophen in horses.

Authors:  S D Meisler; T J Doherty; F M Andrews; D Osborne; D L Frazier
Journal:  Can J Vet Res       Date:  2000-10       Impact factor: 1.310
  2 in total

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