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Literature DB >> 9684051

Phenylbutazone prevents the endotoxin-induced delay in gastric emptying in horses.

N Valk¹, T J Doherty, J T Blackford, T W Abraha, D L Frazier.

Abstract

The effect of phenylbutazone on gastric emptying in horses was determined by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal fasted horses (n = 6), horses given endotoxin intravenously (n = 6), horses given intravenous phenylbutazone (n = 6), and horses given intravenous phenylbutazone plus endotoxin (n = 6). The mean time to reach maximum serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration versus time curve (AUC) were compared among treatment groups. Phenylbutazone did not alter gastric emptying in normal horses. Endotoxin caused a profound delay in gastric emptying, and pretreatment with phenylbutazone abolished this effect.

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Year: 1998 PMID： 9684051 PMCID： PMC1189478

Source DB: PubMed Journal: Can J Vet Res ISSN： 0830-9000 Impact factor: 1.310

15 in total

1. Endotoxin-induced alterations in rat colonic water and electrolyte transport.

Authors: M J Ciancio; L Vitiritti; A Dhar; E B Chang
Journal: Gastroenterology Date: 1992-11 Impact factor: 22.682

2. Effect of endotoxemia on intestinal villus microcirculation in rats.

Authors: H Schmidt; A Secchi; R Wellmann; A Bach; H Böhrer; M M Gebhard; E Martin
Journal: J Surg Res Date: 1996-03 Impact factor: 2.192

3. Antagonism of endotoxin-induced disruption of equine bowel motility by flunixin and phenylbutazone.

Authors: J N King; E L Gerring
Journal: Equine Vet J Suppl Date: 1989-06

4. Effect of bethanechol or erythromycin on gastric emptying in horses.

Authors: N C Ringger; G D Lester; L Neuwirth; A M Merritt; T Vetro; J Harrison
Journal: Am J Vet Res Date: 1996-12 Impact factor: 1.156

5. Blockade of endotoxin-induced cecal hypoperfusion and ileus with an alpha 2 antagonist in horses.

Authors: S C Eades; J N Moore
Journal: Am J Vet Res Date: 1993-04 Impact factor: 1.156

6. Acetaminophen as a marker of gastric emptying in ponies.

Authors: T J Doherty; F M Andrews; M K Provenza; D L Frazier
Journal: Equine Vet J Date: 1998-07 Impact factor: 2.888

7. Effect of cisapride on gastric emptying in horses following endotoxin treatment.

Authors: N Valk; T J Doherty; J T Blackford; T W Abraha; D L Frazier
Journal: Equine Vet J Date: 1998-07 Impact factor: 2.888

8. Gastric emptying of four liquid meals in pony foals.

Authors: S J Baker; E L Gerring
Journal: Res Vet Sci Date: 1994-03 Impact factor: 2.534

9. Detection of endotoxin in cases of equine colic.

Authors: J N King; E L Gerring
Journal: Vet Rec Date: 1988-09-03 Impact factor: 2.695

10. Effects of meals on gastric emptying and small intestinal transit times of a suspension in the beagle dog assessed using acetaminophen and salicylazosulfapyridine as markers.

Authors: H Mizuta; Y Kawazoe; K Haga; K Ogawa
Journal: Chem Pharm Bull (Tokyo) Date: 1990-08 Impact factor: 1.645

4 in total

4. Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys.

Authors: Francisco Javier Mendoza Garcia; Carlos Gonzalez-De Cara; Raul Aguilera-Aguilera; Antonio Buzon-Cuevas; Alejandro Perez-Ecija
Journal: J Vet Intern Med Date: 2020-05-28 Impact factor: 3.333