Literature DB >> 6997277

Substrate channeling: alpha-ketobutyrate inhibition of acetohydroxy acid synthase in Salmonella typhimurium.

K J Shaw, C M Berg.   

Abstract

Excess alpha-ketobutyrate inhibited the growth of Salmonella typhimurium LT2 by inhibiting the acetohydroxy acid synthase-catalyzed synthesis of alpha-acetolactate (a valine precursor). As a result, cells were starved for valine, and both ilvB (encoding acetohydroxy acid synthase I) and ilvGEDA (ilvG encodes acetohydroxy acid synthase II) were derepressed. The addition of valine reversed the effects of alpha-ketobutyrate.

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Year:  1980        PMID： 6997277      PMCID： PMC294547          DOI： 10.1128/jb.143.3.1509-1512.1980

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  8 in total

1.  Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition.

Authors:  N Kleckner; R K Chan; B K Tye; D Botstein
Journal:  J Mol Biol       Date:  1975-10-05       Impact factor: 5.469

2.  Isoleucine and valine metabolism in Escherichia coli. X. The enzymatic formation of acetohydroxybutyrate.

Authors:  R I LEAVITT; H E UMBARGER
Journal:  J Biol Chem       Date:  1961-09       Impact factor: 5.157

3.  Isoleucine and valine metabolism in Escherichia coli. XX. Multiple forms of acetohydroxy acid synthetase.

Authors:  J M Blatt; W J Pledger; H E Umbarger
Journal:  Biochem Biophys Res Commun       Date:  1972-07-25       Impact factor: 3.575

4.  Two forms of biosynthetic acetohydroxy acid synthetase in Salmonella typhimurium.

Authors:  J P O'Neill; M Freundlich
Journal:  Biochem Biophys Res Commun       Date:  1972-07-25       Impact factor: 3.575

5.  Salmonella typhimurium mutants defective in acetohydroxy acid synthases I and II.

Authors:  K J Shaw; C M Berg; T J Sobol
Journal:  J Bacteriol       Date:  1980-03       Impact factor: 3.490

6.  Mutations affecting the formation of acetohydroxy acid synthase II in Escherichia coli K-12.

Authors:  J M Smith; F J Smith; H E Umbarger
Journal:  Mol Gen Genet       Date:  1979-02-01

7.  Improved synthesis of the sodium salt of DL-alpha, beta-dihydroxyisovaleric acid.

Authors:  E A Cioffi; K J Shaw; W F Bailey; C M Berg
Journal:  Anal Biochem       Date:  1980-05-15       Impact factor: 3.365

8.  Physiological characterization of polar Tn5-induced isoleucine-valine auxotrophs in Escherichia coli K.12: evidence for an internal promoter in the ilvOGEDA operon.

Authors:  C M Berg; K J Shaw; J Vender; M Borucka-Mankiewicz
Journal:  Genetics       Date:  1979-10       Impact factor: 4.562
  8 in total
  10 in total

1.  A functional leuABCD operon is required for leucine synthesis by the tyrosine-repressible transaminase in Escherichia coli K-12.

Authors:  N B Vartak; L Liu; B M Wang; C M Berg
Journal:  J Bacteriol       Date:  1991-06       Impact factor: 3.490

Review 2.  Physiology of pyruvate metabolism in Lactococcus lactis.

Authors:  M Cocaign-Bousquet; C Garrigues; P Loubiere; N D Lindley
Journal:  Antonie Van Leeuwenhoek       Date:  1996-10       Impact factor: 2.271

Review 3.  Linkage map of Salmonella typhimurium, Edition VI.

Authors:  K E Sanderson; J R Roth
Journal:  Microbiol Rev       Date:  1983-09

4.  Organization and regulation of the ilvGEDA operon in Salmonella typhimurium LT2.

Authors:  C M Berg; K J Shaw
Journal:  J Bacteriol       Date:  1981-02       Impact factor: 3.490

5.  Involvement of ack-pta operon products in alpha-ketobutyrate metabolism by Salmonella typhimurium.

Authors:  T K Van Dyk; R A LaRossa
Journal:  Mol Gen Genet       Date:  1987-05

6.  Toxic accumulation of alpha-ketobutyrate caused by inhibition of the branched-chain amino acid biosynthetic enzyme acetolactate synthase in Salmonella typhimurium.

Authors:  R A LaRossa; T K Van Dyk; D R Smulski
Journal:  J Bacteriol       Date:  1987-04       Impact factor: 3.490

7.  Sensitivity of a Salmonella typhimurium aspC mutant to sulfometuron methyl, a potent inhibitor of acetolactate synthase II.

Authors:  T K Van Dyk; R A LaRossa
Journal:  J Bacteriol       Date:  1986-02       Impact factor: 3.490

8.  Metabolic basis for the isoleucine, pantothenate or methionine requirement of ilvG strains of Salmonella typhimurium.

Authors:  D A Primerano; R O Burns
Journal:  J Bacteriol       Date:  1982-06       Impact factor: 3.490

9.  Conserved pyridoxal protein that regulates Ile and Val metabolism.

Authors:  Tomokazu Ito; Jumpei Iimori; Sayuri Takayama; Akihito Moriyama; Ayako Yamauchi; Hisashi Hemmi; Tohru Yoshimura
Journal:  J Bacteriol       Date:  2013-10-04       Impact factor: 3.490

10.  Hydroxyamino acid utilization and alpha-ketobutyrate toxicity in Pseudomonas cepacia.

Authors:  H C Wong; P Allenza; T G Lessie
Journal:  J Bacteriol       Date:  1980-10       Impact factor: 3.490
  10 in total

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