Literature DB >> 6245063

Salmonella typhimurium mutants defective in acetohydroxy acid synthases I and II.

K J Shaw, C M Berg, T J Sobol.   

Abstract

An analysis of transposon-induced mutants shows that Salmonella typhimurium possesses two major isozymes of acetohydroxy acid synthase, the enzymes which mediate the first common step in isoleucine and valine biosynthesis. A third (minor) acetohydroxy acid synthase is present, but its significance in isoleucine and valine synthesis may be negligible. Mutants defective in acetohydroxy acid synthase II (ilvG::Tn10) require isoleucine, alpha-ketobutyrate, or threonine for growth, a mutant defective in acetohydroxy acid synthase I (ilvB::Tn5) is a prototroph, and a double mutant (ilvG::Tn10 ilvB::Tn5) requires isoleucine plus valine for growth.

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Year:  1980        PMID： 6245063      PMCID： PMC293821          DOI： 10.1128/jb.141.3.1258-1263.1980

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  15 in total

1.  New Map Location of ilvO in ESCHERICHIA COLI.

Authors:  B M Cohen; E W Jones
Journal:  Genetics       Date:  1976-06       Impact factor: 4.562

2.  Mutant of Escherichia coli K-12 missing acetolactate synthase activity.

Authors:  J Guardiola; M De Felice; M Iaccarino
Journal:  J Bacteriol       Date:  1974-10       Impact factor: 3.490

3.  Temperature-sensitive growth inhibition by valine in Salmonella typhimurium: alteration of one form of acetohydroxy acid synthetase.

Authors:  J P O'Neill; M Freundlich
Journal:  J Bacteriol       Date:  1973-10       Impact factor: 3.490

4.  Isoleucine and valine metabolism in Escherichia coli. XX. Multiple forms of acetohydroxy acid synthetase.

Authors:  J M Blatt; W J Pledger; H E Umbarger
Journal:  Biochem Biophys Res Commun       Date:  1972-07-25       Impact factor: 3.575

5.  Two forms of biosynthetic acetohydroxy acid synthetase in Salmonella typhimurium.

Authors:  J P O'Neill; M Freundlich
Journal:  Biochem Biophys Res Commun       Date:  1972-07-25       Impact factor: 3.575

6.  Structural genes for a newly recognized acetolactate synthase in Escherichia coli K-12.

Authors:  M De Felice; J Guardiola; B Esposito; M Iaccarino
Journal:  J Bacteriol       Date:  1974-12       Impact factor: 3.490

7.  Mutations affecting the formation of acetohydroxy acid synthase II in Escherichia coli K-12.

Authors:  J M Smith; F J Smith; H E Umbarger
Journal:  Mol Gen Genet       Date:  1979-02-01

8.  Expression of a valine-resistant acetolactate synthase activity mediated by the ilv O and ilv G genes of Escherichia coli K-12.

Authors:  R Favre; A Wiater; S Puppo; M Iaccarino
Journal:  Mol Gen Genet       Date:  1976-02-02

9.  Physiological characterization of polar Tn5-induced isoleucine-valine auxotrophs in Escherichia coli K.12: evidence for an internal promoter in the ilvOGEDA operon.

Authors:  C M Berg; K J Shaw; J Vender; M Borucka-Mankiewicz
Journal:  Genetics       Date:  1979-10       Impact factor: 4.562

10.  REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. 3. MAP ORDER OF THE STRUCTURAL GENES AND OPERATOR GENES.

Authors:  T RAMAKRISHNAN; E A ADELBERG
Journal:  J Bacteriol       Date:  1965-03       Impact factor: 3.490
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  20 in total

1.  Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium.

Authors:  George Schmitz; Diana M Downs
Journal:  J Bacteriol       Date:  2004-02       Impact factor: 3.490

2.  Comparison of DeltarelA strains of Escherichia coli and Salmonella enterica serovar Typhimurium suggests a role for ppGpp in attenuation regulation of branched-chain amino acid biosynthesis.

Authors:  K Tedin; F Norel
Journal:  J Bacteriol       Date:  2001-11       Impact factor: 3.490

3.  ilvB-encoded acetolactate synthase is resistant to the herbicide sulfometuron methyl.

Authors:  R A LaRossa; D R Smulski
Journal:  J Bacteriol       Date:  1984-10       Impact factor: 3.490

Review 4.  Linkage map of Salmonella typhimurium, Edition VI.

Authors:  K E Sanderson; J R Roth
Journal:  Microbiol Rev       Date:  1983-09

5.  Molecular structure of ilvIH and its evolutionary relationship to ilvG in Escherichia coli K12.

Authors:  C H Squires; M De Felice; J Devereux; J M Calvo
Journal:  Nucleic Acids Res       Date:  1983-08-11       Impact factor: 16.971

6.  Role of alanine-valine transaminase in Salmonella typhimurium and analysis of an avtA::Tn5 mutant.

Authors:  C M Berg; W A Whalen; L B Archambault
Journal:  J Bacteriol       Date:  1983-09       Impact factor: 3.490

7.  Organization and regulation of the ilvGEDA operon in Salmonella typhimurium LT2.

Authors:  C M Berg; K J Shaw
Journal:  J Bacteriol       Date:  1981-02       Impact factor: 3.490

8.  Metabolic basis for the isoleucine, pantothenate or methionine requirement of ilvG strains of Salmonella typhimurium.

Authors:  D A Primerano; R O Burns
Journal:  J Bacteriol       Date:  1982-06       Impact factor: 3.490

9.  Acetohydroxy acid synthase I is required for isoleucine and valine biosynthesis by Salmonella typhimurium LT2 during growth on acetate or long-chain fatty acids.

Authors:  F E Dailey; J E Cronan; S R Maloy
Journal:  J Bacteriol       Date:  1987-02       Impact factor: 3.490

10.  Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria.

Authors:  Z Barak; D M Chipman; N Gollop
Journal:  J Bacteriol       Date:  1987-08       Impact factor: 3.490
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