Literature DB >> 6992544

Macrophages from adjuvent arthritic rats preferentially synthetize prostacyclin.

I Ahnfelt-Rønne, L Binderup, E Bramm, E Arrigoni-Martelli.   

Abstract

Peritoneal macrophages obtained from rats 21 days after induction of adjuvant arthritis and maintained in culture for 20 h in presence of [14C]-arachidonic acid and 10% foetal calf serum were found to have increased capacity for synthetizing prostacyclin and diminished capacity for synthetizing PGE2 compared with macrophages from normal rats. Similar results were obtained when foetal calf serum was replaced by either normal or arthritic rat serum. Orally administered indomethacin inhibited the increased synthesis of prostacyclin.

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Year:  1980        PMID： 6992544     DOI： 10.1007/bf02024182

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  11 in total

1.  Studies of arthritis and other lesions induced in rats by the injection of mycobacterial adjuvant. VII. Pathologic details of the arthritis and spondylitis.

Authors:  C M PEARSON; F D WOOD
Journal:  Am J Pathol       Date:  1963-01       Impact factor: 4.307

2.  Acidic nonsteroid anti-inflammatory drugs accumulating in inflamed tissue.

Authors:  P Graf; M Glatt; K Brune
Journal:  Experientia       Date:  1975-08-15

3.  Control of lymphokine secretion by prostaglandins.

Authors:  D Gordon; M A Bray; J Morley
Journal:  Nature       Date:  1976-07-29       Impact factor: 49.962

4.  Transformation of arachidonic acid into thromboxane B2 by the homogenates of activated macrophages.

Authors:  S I Murota; M Kawamura; I Morita
Journal:  Biochim Biophys Acta       Date:  1978-03-30

5.  Prostaglandin release from macrophages: an assay system for anti-inflammatory drugs in vitro.

Authors:  M Glatt; H Kälin; K Wagner; K Brune
Journal:  Agents Actions       Date:  1977-09

6.  Regulation of prostaglandin synthesis and of the selective release of lysosomal hydrolases by mouse peritoneal macrophages.

Authors:  R J Bonney; P D Wightman; P Davies; S J Sadowski; F A Kuehl; J L Humes
Journal:  Biochem J       Date:  1978-11-15       Impact factor: 3.857

7.  D-penicillamine and macrophages: modulation of lymphocyte transformation by concanavalin A.

Authors:  L Binderup; E Bramm; E Arrigoni-Martelli
Journal:  Scand J Immunol       Date:  1978-04       Impact factor: 3.487

Review 8.  Prostaglandins, thromboxanes, and polymorphonuclear leukocytes: mediation and modulation of inflammation.

Authors:  I M Goldstein; C L Malmsten; B Samuelsson; G Weissmann
Journal:  Inflammation       Date:  1977-12       Impact factor: 4.092

9.  Rabbit lung microsomes: a rapid method for assaying simultaneously drug effects on thromboxane and prostacyclin synthesis.

Authors:  I Ahnfelt-Rønne; E Arrigoni-Martelli
Journal:  Agents Actions Suppl       Date:  1979

10.  Endogenous inhibitor of prostaglandin synthetase.

Authors:  S A Saeed; W J McDonald-Gibson; J Cuthbert; J L Copas; C Schneider; P J Gardiner; N M Butt; H O Collier
Journal:  Nature       Date:  1977-11-03       Impact factor: 49.962
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  3 in total

1.  Effect of gold salts, D-penicillamine and benoxaprofen on type II collagen-induced arthritis in rats.

Authors:  A J Lewis; R P Carlson; J Chang; F DeLustro
Journal:  Agents Actions       Date:  1984-06

2.  Adjuvant arthritic rat serum enhances HETE1 biosynthesis.

Authors:  I Ahnfelt-Rønne; E Arrigoni-Martelli
Journal:  Agents Actions       Date:  1980-12

3.  A pharmacological analysis of the responses of isolated aorta from rats with adjuvant arthritis.

Authors:  J Fontaine; A Herchuelz; J P Famaey
Journal:  Agents Actions       Date:  1984-06
  3 in total

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