Literature DB >> 6475665

A pharmacological analysis of the responses of isolated aorta from rats with adjuvant arthritis.

J Fontaine, A Herchuelz, J P Famaey.   

Abstract

In order to investigate whether chronic inflammation alters the reactivity of vascular smooth muscle, the effects of various agonists have been compared on isolated aortae from rats with and without arthritis. No significant differences in the EC50 values and maximal responses to 5-hydroxytryptamine (5-HT), noradrenaline (NA) and potassium chloride (KCl) were observed. When calcium was removed from Krebs solution the responses to 5-HT and NA were significantly higher in the preparations from arthritic rats. Verapamil had the same inhibitory effect on the responses of both groups. This suggests that the reactivity of the aortic smooth muscle from arthritic rats is less dependent on extracellular calcium than that of the control preparations.

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Year:  1984        PMID： 6475665     DOI： 10.1007/bf01978908

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  15 in total

1.  SERUM PROTEIN CHANGES IN RATS WITH ARTHRITIS INDUCED BY MYCOBACTERIAL ADJUVANT.

Authors:  J S LOWE
Journal:  Biochem Pharmacol       Date:  1964-04       Impact factor: 5.858

2.  Calcium uptake by sub-cellular membranes from vascular smooth muscle of spontaneously hypertensive rats.

Authors:  K Aoki; K Yamashita; K Hotta
Journal:  Jpn J Pharmacol       Date:  1976-10

Review 3.  Indomethacin--a calcium antagonist.

Authors:  B J Northover
Journal:  Gen Pharmacol       Date:  1977

Review 4.  Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.

Authors:  A Fleckenstein
Journal:  Annu Rev Pharmacol Toxicol       Date:  1977       Impact factor: 13.820

Review 5.  The role of calcium in the action of drugs on vascular smooth muscle.

Authors:  T Godfraind; A Kaba
Journal:  Arch Int Pharmacodyn Ther       Date:  1972-04

6.  Some drug effects on calcium movements in aortic strips.

Authors:  P M Hudgins
Journal:  J Pharmacol Exp Ther       Date:  1969-12       Impact factor: 4.030

7.  The mechanism of contraction of rat aorta to various agonists.

Authors:  V S Krishnamurty; A Grollman
Journal:  Arch Int Pharmacodyn Ther       Date:  1976-04

8.  The role of prostaglandins in experimental arthritis in the rat.

Authors:  Y Floman; E Okon; U Zor
Journal:  Clin Orthop Relat Res       Date:  1977-06       Impact factor: 4.176

9.  Mobilization of cellular calcium and contraction-relaxation of vascular smooth muscle.

Authors:  K Yamashita; T Takagi; K Hotta
Journal:  Jpn J Physiol       Date:  1977

10.  Influence of adjuvant arthritis on main urinary metabolites of prostaglandin F and E in rats.

Authors:  H Honda; K Fukawa; T Sawabe
Journal:  Prostaglandins       Date:  1980-02
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  2 in total

1.  Determination of reactivity of resistance blood vessels in the isolated perfused legs of animals with inflammation as exemplified in adjuvant arthritis.

Authors:  H Bekemeier; R Hirschelmann
Journal:  Agents Actions       Date:  1986-01

2.  Collagen-induced arthritis increases inducible nitric oxide synthase not only in aorta but also in the cardiac and renal microcirculation of mice.

Authors:  G Palma Zochio Tozzato; E F Taipeiro; M A Spadella; P Marabini Filho; M R de Assis; C P Carlos; A P Girol; A B Chies
Journal:  Clin Exp Immunol       Date:  2015-12-10       Impact factor: 4.330
  2 in total

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