Literature DB >> 6930651

Three-dimensional structure of a pyridoxal-phosphate-dependent enzyme, mitochondrial aspartate aminotransferase.

G C Ford, G Eichele, J N Jansonius.   

Abstract

X-ray diffraction studies to 2.8-A resolution have yielded the three-dimensional structure of mitochondrial aspartate aminotransferase (L-aspartate:2-oxoglutarate aminotransferase, EC 2.6.1.1), an isologous alpha 2 dimer (Mr = 2 x 45,000). The subunits are rich in secondary structure and contain two domains, one of which anchors the coenzyme, pyridoxal 5'-phosphate. Each active site lies between the subunits and is composed of residues from both of them.

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Year:  1980        PMID： 6930651      PMCID： PMC349441          DOI： 10.1073/pnas.77.5.2559

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  46 in total

1.  The complete amino acid sequence of cytoplasmic aspartate aminotransferase from pig heart.

Authors:  Y A. Ovchinnikov; C A. Egorov; N A. Aldanova; M Y. Feigina; V M. Lipkin; N G. Abdulaev; E V. Grishin; A P. Kiselev; N N. Modyanov; A E. Braunstein; O L. Polyanovsky; V V. Nosikov
Journal:  FEBS Lett       Date:  1973-01-01       Impact factor: 4.124

2.  Aspartate aminotransferase. Determination of the active site occupancy pattern indicates independent transamination of the two subunits.

Authors:  H Schlegel; P E Zaoralek; P Christen
Journal:  J Biol Chem       Date:  1977-08-25       Impact factor: 5.157

3.  Stereospecificity of sodium borohydride reduction of tyrosine decarboxylase from Streptococcus faecalis.

Authors:  J C Vederas; I D Reingold; H W Sellers
Journal:  J Biol Chem       Date:  1979-06-25       Impact factor: 5.157

4.  The effect of tetranitromethane on apo-aspartate-aminotransferase from pig heart.

Authors:  C Turano; D Barra; F Bossa; A Ferraro; A Giartosio
Journal:  Eur J Biochem       Date:  1971-11-11

5.  On the conformation of proteins: the handedness of the connection between parallel beta-strands.

Authors:  M J Sternberg; J M Thornton
Journal:  J Mol Biol       Date:  1977-02-25       Impact factor: 5.469

6.  Three-dimensional structure at 5 A resolution of cytosolic aspartate transaminase from chicken heart.

Authors:  V V Borisov; S N Borisova; G S Kachalova; N I Sosfenov; B K Vainshtein; Y M Torchinsky; A E Braunstein
Journal:  J Mol Biol       Date:  1978-11-05       Impact factor: 5.469

7.  Primary structure of cytoplasmic aspartate aminotransferase from chicken heart and its homology with pig heart isoenzymes.

Authors:  S V Shlyapnikov; A N Myasnikov; E S Severin; M A Myagkova; Y M Torchinsky; A E Braunstein
Journal:  FEBS Lett       Date:  1979-10-15       Impact factor: 4.124

8.  31P nuclear-magnetic-resonance studies of pyridoxal and pyridoxamine phosphates. Interaction with cytoplasmic aspartate transaminase.

Authors:  M Martinez-Carrion
Journal:  Eur J Biochem       Date:  1975-05

9.  The alpha-helix dipole and the properties of proteins.

Authors:  W G Hol; P T van Duijnen; H J Berendsen
Journal:  Nature       Date:  1978-06-08       Impact factor: 49.962

10.  Location of pyridoxal phosphate in glycogen phosphorylase a.

Authors:  J Sygusch; N B Madsen; P J Kasvinsky; R J Fletterick
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205
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  48 in total

1.  Crystal structure of Trypanosoma cruzi tyrosine aminotransferase: substrate specificity is influenced by cofactor binding mode.

Authors:  W Blankenfeldt; C Nowicki; M Montemartini-Kalisz; H M Kalisz; H J Hecht
Journal:  Protein Sci       Date:  1999-11       Impact factor: 6.725

2.  Heat-induced inactivation and denaturation of mitochondrial aspartate aminotransferase.

Authors:  N V Golub; K A Markosyan; M V Sholukh; N V Kasilovich; S Y Kleimenov; D I Levitskii; B I Kurganov
Journal:  Dokl Biochem Biophys       Date:  2007 Jul-Aug       Impact factor: 0.788

3.  Study of kinetics of thermal aggregation of mitochondrial aspartate aminotransferase by dynamic light scattering: protective effect of alpha-crystallin.

Authors:  Nikolay V Golub; Kira A Markossian; Mikhail V Sholukh; Konstantin O Muranov; Boris I Kurganov
Journal:  Eur Biophys J       Date:  2009-01-27       Impact factor: 1.733

Review 4.  Aspartate aminotransferase: an old dog teaches new tricks.

Authors:  Michael D Toney
Journal:  Arch Biochem Biophys       Date:  2013-10-09       Impact factor: 4.013

5.  Aspartate aminotransferases ofPanicum miliaceum L. andPanicum antidotale retz. : Inactivation and reconstitution.

Authors:  C Balkow; G F Wildner
Journal:  Planta       Date:  1982-09       Impact factor: 4.116

6.  The unfolding and attempted refolding of mitochondrial aspartate aminotransferase from pig heart.

Authors:  S M West; N C Price
Journal:  Biochem J       Date:  1990-01-01       Impact factor: 3.857

7.  Identification and expression of a cDNA clone encoding aspartate aminotransferase in carrot.

Authors:  F J Turano; J M Weisemann; B F Matthews
Journal:  Plant Physiol       Date:  1992-09       Impact factor: 8.340

8.  The dual-mode quaternary structure of seminal RNase.

Authors:  R Piccoli; M Tamburrini; G Piccialli; A Di Donato; A Parente; G D'Alessio
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205

9.  Isolation and characterization of a gene coding for a novel aspartate aminotransferase from Rhizobium meliloti.

Authors:  J R Alfano; M L Kahn
Journal:  J Bacteriol       Date:  1993-07       Impact factor: 3.490

10.  The cloning and sequence analysis of the aspC and tyrB genes from Escherichia coli K12. Comparison of the primary structures of the aspartate aminotransferase and aromatic aminotransferase of E. coli with those of the pig aspartate aminotransferase isoenzymes.

Authors:  I G Fotheringham; S A Dacey; P P Taylor; T J Smith; M G Hunter; M E Finlay; S B Primrose; D M Parker; R M Edwards
Journal:  Biochem J       Date:  1986-03-15       Impact factor: 3.857
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