Literature DB >> 19172260

Study of kinetics of thermal aggregation of mitochondrial aspartate aminotransferase by dynamic light scattering: protective effect of alpha-crystallin.

Nikolay V Golub1, Kira A Markossian, Mikhail V Sholukh, Konstantin O Muranov, Boris I Kurganov.   

Abstract

Thermal aggregation of aspartate aminotransferase from pig heart mitochondria (mAAT) has been studied at various temperatures and various protein concentrations by dynamic light scattering. The character of the dependence of protein aggregate size on time indicates that aggregation of mAAT proceeds in the regime of diffusion-limited cluster-cluster aggregation. Suppression of mAAT aggregation by alpha-crystallin is due to transition of the aggregation process into the regime of reaction-limited cluster-cluster aggregation. Realization of this regime of aggregation means that the sticking probability for the colliding particles is less than unity.

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Year:  2009        PMID： 19172260     DOI： 10.1007/s00249-009-0403-7

Source DB:  PubMed          Journal:  Eur Biophys J        ISSN： 0175-7571            Impact factor:   1.733


  42 in total

Review 1.  Kinetics of protein aggregation. Quantitative estimation of the chaperone-like activity in test-systems based on suppression of protein aggregation.

Authors:  B I Kurganov
Journal:  Biochemistry (Mosc)       Date:  2002-04       Impact factor: 2.487

2.  Mechanism of chaperone-like activity. Suppression of thermal aggregation of betaL-crystallin by alpha-crystallin.

Authors:  Helen A Khanova; Kira A Markossian; Boris I Kurganov; Alexander M Samoilov; Sergey Yu Kleimenov; Dmitrii I Levitsky; Igor K Yudin; Antonina C Timofeeva; Konstantin O Muranov; Michail A Ostrovsky
Journal:  Biochemistry       Date:  2005-11-29       Impact factor: 3.162

3.  Kinetic properties and thermal stabilities of mutant forms of mitochondrial aspartate aminotransferase.

Authors:  A Azzariti; R A Vacca; S Giannattasio; R S Merafina; E Marra; S Doonan
Journal:  Biochim Biophys Acta       Date:  1998-07-28

Review 4.  Protein aggregation: folding aggregates, inclusion bodies and amyloid.

Authors:  A L Fink
Journal:  Fold Des       Date:  1998

Review 5.  Structure and modifications of the junior chaperone alpha-crystallin. From lens transparency to molecular pathology.

Authors:  P J Groenen; K B Merck; W W de Jong; H Bloemendal
Journal:  Eur J Biochem       Date:  1994-10-01

6.  Relation between aggregation kinetics and the structure of kaolinite aggregates.

Authors:  Marta Berka; James A Rice
Journal:  Langmuir       Date:  2005-02-15       Impact factor: 3.882

7.  Mechanism of thermal aggregation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase.

Authors:  Kira A Markossian; Helen A Khanova; Sergey Yu Kleimenov; Dmitrii I Levitsky; Natalia A Chebotareva; Regina A Asryants; Vladimir I Muronetz; Luciano Saso; Igor K Yudin; Boris I Kurganov
Journal:  Biochemistry       Date:  2006-11-07       Impact factor: 3.162

8.  A peptide sequence-YSGVCHTDLHAWHGDWPLPVK [40-60]-in yeast alcohol dehydrogenase prevents the aggregation of denatured substrate proteins.

Authors:  Jaya Bhattacharyya; P Santhoshkumar; K Krishna Sharma
Journal:  Biochem Biophys Res Commun       Date:  2003-07-18       Impact factor: 3.575

9.  [Studies of alpha- and betaL-crystallin complex formation in solution at 60 degrees C].

Authors:  A V Krivandin; K O Muranov; M A Ostrovskiĭ
Journal:  Mol Biol (Mosk)       Date:  2004 May-Jun

10.  Three-dimensional structure of a pyridoxal-phosphate-dependent enzyme, mitochondrial aspartate aminotransferase.

Authors:  G C Ford; G Eichele; J N Jansonius
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205
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  4 in total

1.  Comparative analysis of the effects of alpha-crystallin and GroEL on the kinetics of thermal aggregation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase.

Authors:  Kira A Markossian; Nikolay V Golub; Natalia A Chebotareva; Regina A Asryants; Irina N Naletova; Vladimir I Muronetz; Konstantin O Muranov; Boris I Kurganov
Journal:  Protein J       Date:  2010-01       Impact factor: 2.371

2.  A protein aggregation based test for screening of the agents affecting thermostability of proteins.

Authors:  Tatyana Eronina; Vera Borzova; Olga Maloletkina; Sergey Kleymenov; Regina Asryants; Kira Markossian; Boris Kurganov
Journal:  PLoS One       Date:  2011-07-08       Impact factor: 3.240

3.  Kinetics of Thermal Denaturation and Aggregation of Bovine Serum Albumin.

Authors:  Vera A Borzova; Kira A Markossian; Natalia A Chebotareva; Sergey Yu Kleymenov; Nikolay B Poliansky; Konstantin O Muranov; Vita A Stein-Margolina; Vladimir V Shubin; Denis I Markov; Boris I Kurganov
Journal:  PLoS One       Date:  2016-04-21       Impact factor: 3.240

Review 4.  Mechanism of suppression of protein aggregation by α-crystallin.

Authors:  Kira A Markossian; Igor K Yudin; Boris I Kurganov
Journal:  Int J Mol Sci       Date:  2009-03-19       Impact factor: 6.208
  4 in total

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