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Literature DB >> 661956

The alpha-helix dipole and the properties of proteins.

W G Hol, P T van Duijnen, H J Berendsen.

Abstract

Phosphate moieties bind frequently at N-termini of helices in proteins. It is shown that this corresponds with an optimal interaction of the helix dipole and the charged phosphate. This favourable arrangement may have been discovered several times during evolution. In some enzymes, the helix dipole might be used in catalysis.

Entities: Chemical Mutation

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Year: 1978 PMID： 661956 DOI： 10.1038/273443a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

174 in total

1. Permeation of ions across the potassium channel: Brownian dynamics studies.

Authors: S H Chung; T W Allen; M Hoyles; S Kuyucak
Journal: Biophys J Date: 1999-11 Impact factor: 4.033

2. Molecular dynamics study of the KcsA potassium channel.

Authors: T W Allen; S Kuyucak; S H Chung
Journal: Biophys J Date: 1999-11 Impact factor: 4.033

3. The high-resolution crystal structure of the molybdate-dependent transcriptional regulator (ModE) from Escherichia coli: a novel combination of domain folds.

Authors: D R Hall; D G Gourley; G A Leonard; E M Duke; L A Anderson; D H Boxer; W N Hunter
Journal: EMBO J Date: 1999-03-15 Impact factor: 11.598

Review 4. Classification of protein folds.

Authors: Robert B Russell
Journal: Mol Biotechnol Date: 2002-01 Impact factor: 2.695

5. Structure and topological symmetry of the glyphosate target 5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold.

Authors: W C Stallings; S S Abdel-Meguid; L W Lim; H S Shieh; H E Dayringer; N K Leimgruber; R A Stegeman; K S Anderson; J A Sikorski; S R Padgette; G M Kishore
Journal: Proc Natl Acad Sci U S A Date: 1991-06-01 Impact factor: 11.205

6. Noncharged amino acid residues at the solvent-exposed positions in the middle and at the C terminus of the alpha-helix have the same helical propensity.

Authors: Dmitri N Ermolenko; John M Richardson; George I Makhatadze
Journal: Protein Sci Date: 2003-06 Impact factor: 6.725

The alpha-helix dipole and the properties of proteins.

1. Permeation of ions across the potassium channel: Brownian dynamics studies.

2. Molecular dynamics study of the KcsA potassium channel.

3. The high-resolution crystal structure of the molybdate-dependent transcriptional regulator (ModE) from Escherichia coli: a novel combination of domain folds.

Review 4. Classification of protein folds.

5. Structure and topological symmetry of the glyphosate target 5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold.

6. Noncharged amino acid residues at the solvent-exposed positions in the middle and at the C terminus of the alpha-helix have the same helical propensity.

7. Role of loop-helix interactions in stabilizing four-helix bundle proteins.

8. Strong electrostatic loop-helix interactions in bundle motif protein structures.

9. The properties of ion channels formed by zervamicins.

10. Alamethicin and related peptaibols--model ion channels.