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Literature DB >> 6891340

Whole brain methionine-enkephalin of ethanol-avoiding and ethanol-preferring c57BL mice.

K Blum, A H Briggs, L DeLallo, S F Elston, R Ochoa.

Abstract

These experiments systematically investigated ethanol preference in both the C57Bl/6N and C57Bl/6J mice utilizing three-choice 2-bottle preference test. In addition, these sublines were evaluated for whole brain methionine-enkephalin levels, which were significantly lower in C57Bl/6J mice (alcohol preferring) compared to C57Bl/6N mice (alcohol non-preferring). This finding supports the involvement of the peptidyl opiates in ethanol seeking behavior.

Entities: Chemical Species

Mesh：

Substances：
Enkephalin, Methionine

Year: 1982 PMID： 6891340 DOI： 10.1007/bf01955775

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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1. Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies.

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Review 2. The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms.

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Authors: Anna S Warden; Adriana DaCosta; Sonia Mason; Yuri A Blednov; Roy Dayne Mayfield; Robert Adron Harris
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7. Neurogenetics and Nutrigenomics of Neuro-Nutrient Therapy for Reward Deficiency Syndrome (RDS): Clinical Ramifications as a Function of Molecular Neurobiological Mechanisms.

Authors: Kenneth Blum; Marlene Oscar-Berman; Elizabeth Stuller; David Miller; John Giordano; Siobhan Morse; Lee McCormick; William B Downs; Roger L Waite; Debmalya Barh; Dennis Neal; Eric R Braverman; Raquel Lohmann; Joan Borsten; Mary Hauser; David Han; Yijun Liu; Manya Helman; Thomas Simpatico
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