Literature DB >> 5460776

Alcohol, amines, and alkaloids: a possible biochemical basis for alcohol addiction.

V E Davis, M J Walsh.   

Abstract

Tetrahydropapaveroline is a benzyltetrahydroisoquinoline alkaloidderivative of the biogenic amine, dopnmine. Alcohol, by way of its primary metabolite, acetaldehyde, competitively inhibits nicotinamide-adenine Sinucleotide-linked aldehyde dehydrogenase and augments the formation of tetrahydropapaveroline in vitro. The limited capacity of brain to oxidize aldehydes may be of pharmacological importance because it facilitates the production of tetrahydropapaveroline in the presence of drugs which inhibit this enzyme.

Entities:  

Mesh：

Substances：

Year:  1970        PMID： 5460776     DOI： 10.1126/science.167.3920.1005

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  63 in total

Review 1.  Endorphins: the basis of pleasure?

Authors:  C H Hawkes
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-04       Impact factor: 10.154

2.  [Chemical mechanism of the effect of alcohol].

Authors:  G Bringmann
Journal:  Naturwissenschaften       Date:  1979-01

3.  Genetic and early environmental contributions to alcohol's aversive and physiological effects.

Authors:  Peter G Roma; Jennifer A Rinker; Katherine M Serafine; Scott A Chen; Christina S Barr; Kejun Cheng; Kenner C Rice; Anthony L Riley
Journal:  Pharmacol Biochem Behav       Date:  2008-06-29       Impact factor: 3.533

4.  Analgesic effects of 3-carboxysalsolinol alone and in combination with morphine.

Authors:  A Marshall; M Hirst; K Blum
Journal:  Experientia       Date:  1977-06-15

5.  Fifty Years in the Development of a Glutaminergic-Dopaminergic Optimization Complex (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome: A Pictorial.

Authors:  K Blum; M Febo; R D Badgaiyan
Journal:  Austin Addict Sci       Date:  2016-10-12

6.  Morphine suppression of ethanol withdrawal in mice.

Authors:  K Blum; J E Wallace; H A Schwerter; J D Eubanks
Journal:  Experientia       Date:  1976-01-15

7.  Protective action of ascorbic acid and sulfur compounds against acetaldehyde toxicity: implications in alcoholism and smoking.

Authors:  H Sprince; C M Parker; G G Smith; L J Gonzales
Journal:  Agents Actions       Date:  1975-05

8.  A critical evaluation of influence of ethanol and diet on salsolinol enantiomers in humans and rats.

Authors:  Jeongrim Lee; Vijay A Ramchandani; Kei Hamazaki; Eric A Engleman; William J McBride; Ting-Kai Li; Hee-Yong Kim
Journal:  Alcohol Clin Exp Res       Date:  2009-11-24       Impact factor: 3.455

9.  Locomotor stimulant effects of acute and repeated intrategmental injections of salsolinol in rats: role of mu-opioid receptors.

Authors:  Lucía Hipólito; María-José Sánchez-Catalán; Teodoro Zornoza; Ana Polache; Luis Granero
Journal:  Psychopharmacology (Berl)       Date:  2010-03       Impact factor: 4.530

10.  [Serotonin metabolism in chronic alcoholism (author's transl)].

Authors:  R H Rolf; D R Matz; G G Brune
Journal:  Experientia       Date:  1978-01-15
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.