Literature DB >> 6579537

Ethanol acceptance as a function of genotype amounts of brain [Met]enkephalin.

K Blum, S F Elston, L DeLallo, A H Briggs, J E Wallace.   

Abstract

Our results indicate a negative correlation between the amount of ethanol (10%) consumed and endogenous levels of brain [Met]enkephalin in C57BL/6J (alcohol-preferring) and DBA/2J (alcohol-nonpreferring) inbred mice strains. Additionally, it was found that 8 wk after 1-day starved groups of both C57BL/6J and DBA/2J mice were challenged with ethanol (10%) for 1-day acceptance, they had significantly lower levels of brain [Met]enkephalin compared with their nonalcohol-treated controls. These results suggest that the brain endogenous peptidyl opiates may play a crucial role in alcohol-seeking behavior.

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Year:  1983        PMID： 6579537      PMCID： PMC390382          DOI： 10.1073/pnas.80.21.6510

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

1.  Interactions of narcotics, narcotic antagonists, and ethanol during acute, chronic, and withdrawal states.

Authors:  A K Ho; R C Chen
Journal:  Ann N Y Acad Sci       Date:  1976       Impact factor: 5.691

2.  Morphine-induced suppression of voluntary alcohol drinking in rats.

Authors:  J D Sinclair; J Adkins; S Walker
Journal:  Nature       Date:  1973-12-14       Impact factor: 49.962

3.  Suppression of ethanol consumption by MET-enkephalin in rats.

Authors:  A K Ho; N Rossi
Journal:  J Pharm Pharmacol       Date:  1982-02       Impact factor: 3.765

4.  Opiate-like activity of salsolinol on the electrically stimulated guinea pig ileum.

Authors:  M G Hamilton; M Hirst; K Blum
Journal:  Life Sci       Date:  1979-12-24       Impact factor: 5.037

5.  Alcohol and the opiate receptor.

Authors:  A S Levine; S Hess; J E Morley
Journal:  Alcohol Clin Exp Res       Date:  1983       Impact factor: 3.455

Review 6.  Alcohol-related tetrahydroisoquinolines: pharmacology and identification.

Authors:  M G Hamilton; M Hirst
Journal:  Subst Alcohol Actions Misuse       Date:  1980

7.  Ethanol preference as a function of genotypic levels of whole brain enkephalin in mice.

Authors:  K Blum; A H Briggs; S F Elston; L DeLallo
Journal:  Toxicol Eur Res       Date:  1981-09

8.  Naloxone alters alcohol drinking induced in the rat by tetrahydropapaveroline (THP) infused ICV.

Authors:  R D Myers; E C Critcher
Journal:  Pharmacol Biochem Behav       Date:  1982-05       Impact factor: 3.533

9.  Ethanol preference in the hamster: effects of morphine sulfate and naltrexone, a long-acting morphine antagonist.

Authors:  D Ross; R J Hartmann; I Geller
Journal:  Proc West Pharmacol Soc       Date:  1976

10.  Multiple opiate receptors: alcohol selectively inhibits binding to delta receptors.

Authors:  J M Hiller; L M Angel; E J Simon
Journal:  Science       Date:  1981-10-23       Impact factor: 47.728
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  20 in total

1.  Importance of delta opioid receptors in maintaining high alcohol drinking.

Authors:  J C Froehlich; M Zweifel; J Harts; L Lumeng; T K Li
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

Review 2.  Delivering peptides to the central nervous system: dilemmas and strategies.

Authors:  W A Banks; A J Kastin; C M Barrera
Journal:  Pharm Res       Date:  1991-11       Impact factor: 4.200

Review 3.  The new disease model of alcoholism.

Authors:  J Wallace
Journal:  West J Med       Date:  1990-05

4.  Administration of a putative pro-dopamine regulator, a neuronutrient, mitigates alcohol intake in alcohol-preferring rats.

Authors:  Naimesh Solanki; Tomilowo Abijo; Carine Galvao; Philippe Darius; Kenneth Blum; Marjorie C Gondré-Lewis
Journal:  Behav Brain Res       Date:  2020-02-15       Impact factor: 3.332

5.  Fifty Years in the Development of a Glutaminergic-Dopaminergic Optimization Complex (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome: A Pictorial.

Authors:  K Blum; M Febo; R D Badgaiyan
Journal:  Austin Addict Sci       Date:  2016-10-12

6.  Hypothesizing That Neuropharmacological and Neuroimaging Studies of Glutaminergic-Dopaminergic Optimization Complex (KB220Z) Are Associated With "Dopamine Homeostasis" in Reward Deficiency Syndrome (RDS).

Authors:  Kenneth Blum; Marcelo Febo; Lyle Fried; Mona Li; Kristina Dushaj; Eric R Braverman; Thomas McLaughlin; Bruce Steinberg; Rajendra D Badgaiyan
Journal:  Subst Use Misuse       Date:  2016-12-29       Impact factor: 2.164

7.  Regional brain [Met]-enkephalin in alcohol-preferring and non-alcohol-preferring inbred strains of mice.

Authors:  K Blum; A H Briggs; J E Wallace; C W Hall; M A Trachtenberg
Journal:  Experientia       Date:  1987-04-15

8.  Hypothesizing Darkness Induced Alcohol Intake Linked to Dopaminergic Regulation of Brain Function.

Authors:  Kenneth Blum; Marlene Oscar-Berman; Rajendra Badgaiyan; Eric R Braverman; Mark S Gold
Journal:  Psychology (Irvine)       Date:  2014-03

9.  Neurogenetics and Nutrigenomics of Neuro-Nutrient Therapy for Reward Deficiency Syndrome (RDS): Clinical Ramifications as a Function of Molecular Neurobiological Mechanisms.

Authors:  Kenneth Blum; Marlene Oscar-Berman; Elizabeth Stuller; David Miller; John Giordano; Siobhan Morse; Lee McCormick; William B Downs; Roger L Waite; Debmalya Barh; Dennis Neal; Eric R Braverman; Raquel Lohmann; Joan Borsten; Mary Hauser; David Han; Yijun Liu; Manya Helman; Thomas Simpatico
Journal:  J Addict Res Ther       Date:  2012-11-27

10.  Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry.

Authors:  Trevor Archer; Marlene Oscar-Berman; Kenneth Blum; Mark Gold
Journal:  J Genet Syndr Gene Ther       Date:  2012-05-30
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