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Literature DB >> 687509

Effect of an implanted Walker tumour on metabolism of folic acid in the rat.

Abstract

The metabolism of 2-[14C] folic acid has been studied in rats with an implanted Walker 256 tumour and in a closely matched group of controls. In animals with tumours, more of the labelled folic acid is converted to 10-formyltetrahydrofolate and 10-formylfolate than in normal animals. No 5-methyltetrahydrofolate could be detected in tumour tissue, or in the livers of tumour-bearing animals. When a mixture of 2-[14C]- and 3',5',9-[3H]-folic acid is given to tumour-bearing rats a similar pattern of metabolites is found. There is apparenly less scission of the folate molecule in tumour-bearing rats than in normal rats.

Entities: Chemical Disease Species

Mesh：

Substances：
Folic Acid

Year: 1978 PMID： 687509 PMCID： PMC2009699 DOI： 10.1038/bjc.1978.171

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

16 in total

1. The effect of methotrexate on the metabolism of [14C]folates in the rat.

Authors: P A Barford; J A Blair; M A Malghani
Journal: Biochem Soc Trans Date: 1976 Impact factor: 5.407

2. The elucidation of the mechanism of folate catabolism in the rat.

Authors: M Murphy; M Keating; P Boyle; D G Weir; J M Scott
Journal: Biochem Biophys Res Commun Date: 1976-08-23 Impact factor: 3.575

3. Isolation, purification, characterization and metabolism of high-molecular-weight folate from rat liver [proceedings].

Authors: M J Connor; J A Blair; P A Barford
Journal: Biochem Soc Trans Date: 1977 Impact factor: 5.407

4. Retained folates in the rat.

Authors: P A Barford; R J Staff; J A Blair
Journal: Biochem J Date: 1977-06-15 Impact factor: 3.857

5. The enzymology of the formation and interconversion of labile 1-carbon groups in five hepatomas and in Walker tumor 256.

Authors: R Lepage; L A Poirier; M C Poirier; H P Morris
Journal: Cancer Res Date: 1972-06 Impact factor: 12.701

6. Hydroxylated derivatives of 5-methyl-5,6,7,8-tetrahydrofolate.

Authors: G R Gapski; J M Whiteley; F M Huennekens
Journal: Biochemistry Date: 1971-07-20 Impact factor: 3.162

7. The metabolism of folates in the rat: studies with 3H- and 14C-labelled folic acid in the presence and in the absence of methotrexate [proceedings].

Authors: P A Barford; J A Blair; F J Staff; M A Malghani
Journal: Biochem Soc Trans Date: 1977 Impact factor: 5.407

8. A convenient method for the preparation of dl-5-methyltetrahydrofolic acid (dl-5-methyl-5,6,7,8-tetrahydropteroyl-L-monoglutamic acid).

Authors: J A Blair; K J Saunders
Journal: Anal Biochem Date: 1970-04 Impact factor: 3.365

9. The reaction of tetrahydropteroylglutamic acid and related hydropteridines with formaldehyde.

Authors: R L BLAKLEY
Journal: Biochem J Date: 1959-08 Impact factor: 3.857

10. Pterin-6-aldehyde, a cancer cell catabolite: identification and application in diagnosis and treatment of human cancer.

Authors: R Halpern; B C Halpern; B Stea; A Dunlap; K Conklin; B Clark; H Ashe; L Sperling; J A Halpern; D Hardy; R A Smith
Journal: Proc Natl Acad Sci U S A Date: 1977-02 Impact factor: 11.205

7 in total

1. Bioactivity of [6R]-5-formyltetrahydrofolate, an unusual isomer, in humans and Enterococcus hirae, and cytochrome c oxidation of 10-formytetrahydrofolate to 10-formyldihydrofolate.

Authors: J E Baggott; C B Robinson; K E Johnston
Journal: Biochem J Date: 2001-02-15 Impact factor: 3.857

2. Cofactor role for 10-formyldihydrofolic acid.

Authors: J E Baggott; G L Johanning; K E Branham; C W Prince; S L Morgan; I Eto; W H Vaughn
Journal: Biochem J Date: 1995-06-15 Impact factor: 3.857

3. The identification of p-acetamidobenzoate as a folate degradation product in rat urine.

Authors: M J Connor; A E Pheasant; J A Blair
Journal: Biochem J Date: 1979-03-15 Impact factor: 3.857

4. A survey of the location, isolation and identification of indoles, pteridines and some unknown active substances in sheep pineals. The possible significance of pteridines for the neuroendocrine control of neoplastic growth.

Authors: I Ebels
Journal: J Neural Transm Date: 1980 Impact factor: 3.575