| Literature DB >> 6976181 |
A M Saleh, A E Pheasant, J A Blair.
Abstract
The metabolism of (2-14C) + (3',5',7,9-3H) folic acid was studied in normal rats, tumour-bearing rats and rats treated with methotrexate (MTX). The experiments were designed to investigate changes in the catabolism and folate. The breakdown of folate to scission products was again demonstrated to be a normal phenomenon. Catabolites excreted included p-acetamidobenzoate, p-acetamidobenzoyl-L-glutamate, 3H2O, urea and a number of pterins. The catabolic process was decreased in the presence of a tumour and increased by the administration of MTX. MTX also led to the excretion of 4 additional radioactive pterins not found in normal urine. The possible mechanisms of folate breakdown are discussed with reference to the point of action of MTX.Entities:
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Year: 1981 PMID： 6976181 PMCID： PMC2010830 DOI： 10.1038/bjc.1981.256
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640