Literature DB >> 454383

The identification of p-acetamidobenzoate as a folate degradation product in rat urine.

M J Connor, A E Pheasant, J A Blair.   

Abstract

Within 48 h of administration of radiolabelled 10-formylfolate, folic acid and the polyglutamate derivative 10-formylfolate tetraglutamate to the rat, fragmentation products are found in the urine. The major catabolite was identified as p-acetamidobenzoate by chromatography and reverse isotope-dilution analysis.

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Year:  1979        PMID： 454383      PMCID： PMC1186581          DOI： 10.1042/bj1780795

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  ANALOGS OF TETRAHYDROFOLIC ACID. X. SYNTHETIC AND ENZYMIC STUDIES ON THE CONTRIBUTION OF THE P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES.

Authors:  B R BAKER; D V SANTI; P I ALMAULA; W C WERKEISER
Journal:  J Med Chem       Date:  1964-01       Impact factor: 7.446

2.  Isolation of isoxanthopterin from human urine.

Authors:  J A BLAIR
Journal:  Biochem J       Date:  1958-03       Impact factor: 3.857

3.  Studies on the metabolism of para-aminobenzoic acid.

Authors:  C W TABOR; M V FREEMAN; J BAILY; P K SMITH
Journal:  J Pharmacol Exp Ther       Date:  1951-06       Impact factor: 4.030

4.  The elucidation of the mechanism of folate catabolism in the rat.

Authors:  M Murphy; M Keating; P Boyle; D G Weir; J M Scott
Journal:  Biochem Biophys Res Commun       Date:  1976-08-23       Impact factor: 3.575

5.  Isolation, purification, characterization and metabolism of high-molecular-weight folate from rat liver [proceedings].

Authors:  M J Connor; J A Blair; P A Barford
Journal:  Biochem Soc Trans       Date:  1977       Impact factor: 5.407

6.  Studies of the metabolism of methotrexate by intestinal flora. I. Identification and study of biological properties of the metabolite 4-amino-4-deoxy-N 10 -methylpteroic acid.

Authors:  D M Valerino; D G Johns; D S Zaharko; V T Oliverio
Journal:  Biochem Pharmacol       Date:  1972-03-15       Impact factor: 5.858

7.  Alcohol interference with the folate enterohepatic cycle.

Authors:  R S Hillman; R McGuffin; C Campbell
Journal:  Trans Assoc Am Physicians       Date:  1977

8.  The reaction of tetrahydropteroylglutamic acid and related hydropteridines with formaldehyde.

Authors:  R L BLAKLEY
Journal:  Biochem J       Date:  1959-08       Impact factor: 3.857

9.  The identification of the products of folate catabolism in the rat.

Authors:  M Murphy; P H Boyle; D G Weir; J M Scott
Journal:  Br J Haematol       Date:  1978-02       Impact factor: 6.998

10.  Effect of an implanted Walker tumour on metabolism of folic acid in the rat.

Authors:  P A Barford; J A Blair
Journal:  Br J Cancer       Date:  1978-07       Impact factor: 7.640
  10 in total
  9 in total

1.  Early increase of plasma homocysteine in sepsis patients with poor outcome.

Authors:  Martin Ploder; Katharina Kurz; Andreas Spittler; Gabriele Neurauter; Erich Roth; Dietmar Fuchs
Journal:  Mol Med       Date:  2010-03-26       Impact factor: 6.354

2.  The metabolism of 5-methyltetrahydropteroyl-L-glutamic acid and its oxidation products in the rat.

Authors:  J C Kennelly; J A Blair; A E Pheasant
Journal:  Biochem J       Date:  1982-08-15       Impact factor: 3.857

3.  The identification of the folate conjugates found in rat liver 48 h after the administration of radioactively labelled folate tracers.

Authors:  M J Connor; J A Blair
Journal:  Biochem J       Date:  1980-01-15       Impact factor: 3.857

4.  Metabolism of 5-methyltetrahydrofolate by rats bearing the Walker 256 carcinosarcoma.

Authors:  J C Kennelly; J A Blair; A E Pheasant
Journal:  Br J Cancer       Date:  1982-09       Impact factor: 7.640

5.  Comparison of Substrate Specificity of Escherichia Coli p-Aminobenzoyl-Glutamate Hydrolase with Pseudomonas Carboxypeptidase G.

Authors:  Cassandra M Larimer; Dejan Slavnic; Lenore D Pitstick; Jacalyn M Green
Journal:  Adv Enzyme Res       Date:  2014-03

6.  Folate metabolism in man: the effect of malignant disease.

Authors:  A M Saleh; A E Pheasant; J A Blair; R N Allan; J Walters
Journal:  Br J Cancer       Date:  1982-09       Impact factor: 7.640

7.  Investigations of tissue folates in normal and malignant tissues.

Authors:  A E Pheasant; J Bates; J A Blair; R Nayyir-Mazhir
Journal:  Br J Cancer       Date:  1983-03       Impact factor: 7.640

8.  Folate catabolism in tumour-bearing rats and rats treated with methotrexate.

Authors:  A M Saleh; A E Pheasant; J A Blair
Journal:  Br J Cancer       Date:  1981-11       Impact factor: 7.640

9.  The effect of methotrexate on folate metabolism in the rat.

Authors:  P A Barford; J A Blair; M A Malghani
Journal:  Br J Cancer       Date:  1980-05       Impact factor: 7.640
  9 in total

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