Literature DB >> 6864720

Chemotherapy of chemically-induced colorectal tumours.

J M Gilbert, E M Thompson, G Slavin, A E Kark.   

Abstract

Benign and malignant tumours were induced in the large bowel of rats by the carcinogen 1,2-dimethylhydrazine (DMH). Benign tumours appeared from week 20 onwards and malignant tumours from week 30. 5-Fluorouracil was administered intraperitoneally in maximally tolerated doses from week 26 onwards and failed to influence significantly the development of either benign or malignant tumours. Tumours induced by DMH are a close model of human colorectal cancer and suitable for testing anticancer drugs. Agents with greater activity against colorectal cancer are required.

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Year:  1983        PMID： 6864720      PMCID： PMC1439211     

Source DB:  PubMed          Journal:  J R Soc Med        ISSN： 0141-0768            Impact factor:   5.344


  17 in total

1.  Chemotherapy of gastrointestinal cancer.

Authors:  C G Moertel
Journal:  Clin Gastroenterol       Date:  1976-09

2.  Evaluation of single agents and combinations of chemotherapeutic agents in mouse colon carcinomas.

Authors:  T H Corbett; D P Griswold; B J Roberts; J C Peckham; F M Schabel
Journal:  Cancer       Date:  1977-11       Impact factor: 6.860

Review 3.  Chemotherapy of gastrointestinal cancer.

Authors:  C G Moertel
Journal:  N Engl J Med       Date:  1978-11-09       Impact factor: 91.245

4.  A second look at the second operation in colonic cancer after the administration of fluorouracil.

Authors:  S Mackman; F J Ansfield; G Ramirez; A R Curreri
Journal:  Am J Surg       Date:  1974-12       Impact factor: 2.565

5.  Second-look operation for colon carcinoma after fluorouracil therapy.

Authors:  S Mackman; A R Curreri; F J Ansfield
Journal:  Arch Surg       Date:  1970-04

6.  Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

Authors:  E J Freireich; E A Gehan; D P Rall; L H Schmidt; H E Skipper
Journal:  Cancer Chemother Rep       Date:  1966-05

7.  Chemotherapy studies in autochthonous rat tumors intestinal cancer.

Authors:  F Sych; M Habs; D Schmähl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1978-08-24

8.  Cancer chemotherapy model using autochthonous large bowel cancer in rats.

Authors:  T Narisawa; K Kono; T Yamaguchi; T Takahashi
Journal:  Gan       Date:  1978-06

9.  Corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats.

Authors:  J P Cruse; M R Lewin; C G Clark
Journal:  Br J Cancer       Date:  1978-04       Impact factor: 7.640

10.  Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine. A morphological and histochemical study.

Authors:  M I Filipe
Journal:  Br J Cancer       Date:  1975-07       Impact factor: 7.640
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  3 in total

1.  Experimental colorectal cancer as a model of human disease.

Authors:  J M Gilbert
Journal:  Ann R Coll Surg Engl       Date:  1987-03       Impact factor: 1.891

2.  The metastatic stage-dependent mucosal expression of sialic acid is a potential marker for targeting colon cancer with cationic polymers.

Authors:  Abdel Kareem Azab; Jackie Kleinstern; Morris Srebnik; Abraham Rubinstein
Journal:  Pharm Res       Date:  2007-10-25       Impact factor: 4.200

3.  Experimental colon neoplasia enhanced by extract of sperm (protamine).

Authors:  R K Phillips; D S Quill; H A Dudley
Journal:  J R Soc Med       Date:  1984-10       Impact factor: 5.344
  3 in total

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