| Literature DB >> 6492040 |
R K Phillips, D S Quill, H A Dudley.
Abstract
An experimental study of colorectal tumorigenesis in inbred rats given the potent carcinogen dimethylhydrazine has shown that protamine, given before any tumours had developed, significantly enhanced the development of large bowel tumours (100% incidence). Those animals having no adjuvant therapy or who received either heparin or 5-fluorouracil (alone or in combination) had an approximate 50% incidence of such tumours.Entities:
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Year: 1984 PMID： 6492040 PMCID： PMC1440280 DOI： 10.1177/014107688407701005
Source DB: PubMed Journal: J R Soc Med ISSN： 0141-0768 Impact factor: 5.344