Literature DB >> 151400

Chemotherapy studies in autochthonous rat tumors intestinal cancer.

F Sych, M Habs, D Schmähl.   

Abstract

Intestinal tumors in rats were induced by three different chemical carcinogens. Only tumors induced by 1,2-dimethylhydrazine responded slightly to combination chemotherapy of Adriamycin, Methotrexate, 5-Fluorouracil, and Cyclophosphamide. The same therapy failed in tumors induced by N-methyl-N'-nitro-N-nitroso-guanidine or acetoxymethyl-methyl-nitrosamine. These results and the comparability of chemotherapy in autochthonous tumors to experimental and clinical observations are discussed.

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Year:  1978        PMID： 151400     DOI： 10.1007/bf00284097

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN： 0084-5353


  35 in total

1.  [CHEMOTHERAPY EXPERIMENTS ON AUTOCHTHONOUS AUDITORY CANAL CARCINOMA IN RATS].

Authors:  D SCHMAEHL; G SCHRICK
Journal:  Arzneimittelforschung       Date:  1964-01

2.  Chemotherapy of two morphologically similar human tumors growing in the cheek pouch of the golden hamster: H. Ad. No. 1 and GW--39.

Authors:  D M Goldenberg; S Witte
Journal:  Eur J Cancer       Date:  1967-06       Impact factor: 9.162

3.  Induction of carcinomas of the colon and rectum in rats by intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  B T So; N E Magadia; E L Wynder
Journal:  J Natl Cancer Inst       Date:  1973-04       Impact factor: 13.506

4.  Carcinoma of the colon and rectum of rats by rectal infusion of N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  T Narisawa; T Sato; M Hayakawa; A Sakuma; H Nakano
Journal:  Gan       Date:  1971-06

5.  Classification of human colorectal adenocarcinoma cell lines.

Authors:  A Leibovitz; J C Stinson; W B McCombs; C E McCoy; K C Mazur; N D Mabry
Journal:  Cancer Res       Date:  1976-12       Impact factor: 12.701

6.  A colon tumor model for anticancer agent evaluation.

Authors:  D P Griswold; T H Corbett
Journal:  Cancer       Date:  1975-12       Impact factor: 6.860

7.  Effect of vitamin A deficiency on rat colon carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  T Narisawa; B S Reddy; C Q Wong; J H Weisburger
Journal:  Cancer Res       Date:  1976-04       Impact factor: 12.701

8.  [On the carcinogenic action of N-nitroso-compounds. 5th Communication: acetoxymethyl-methyl-nitrosamine (author's transl)].

Authors:  M Wiessler; D Schmähl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-01-02

9.  Chemotherapy studies in autochthonous rat tumors. Forestomach and bladder cancer.

Authors:  M Habs; J Ang; D Schmähl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-06-27

10.  Experimental investigations on the influence upon the chemical carcinogenesis. IIIrd communication: studies with 1,2-dimethylhydrazine.

Authors:  D Schmähl; A Danisman; M Habs; B Diehl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-05-03
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  14 in total

1.  Chemotherapy studies in autochthonous rat tumors: carcinomas of the forestomach.

Authors:  M Habs; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1979-09       Impact factor: 4.553

2.  [Effect of local moderate hyperthermia in combination with N-nitroso-1,3-bis-(2-chloroethyl)urea (BCNU) and 5-fluoro-(tetrahydro-2-furyl)uracil (ftorafur) on induced autochthonous colonic cancers in the rat. 3: Polychemotherapy in combination with hyperthermia].

Authors:  E Biwer; M Lorenz; M Habs; D Schmähl
Journal:  Langenbecks Arch Chir       Date:  1984

3.  Experimental chemotherapy with N'N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) in autochthonous neurogenic tumors of the rat transplacentally induced by ethylnitrosourea.

Authors:  H H Fiebig; H Strobel; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

4.  Combination chemotherapy with 5-fluorouracil (5FU) and 1,3-bis(2-chloro-ethyl)-1-nitrosourea (BCNU) prolongs survival of rats with dimethylhydrazine-induced colon cancer.

Authors:  M Danzi; M R Lewin; J P Cruse; C G Clark
Journal:  Gut       Date:  1983-11       Impact factor: 23.059

5.  Treatment of autochthonous rat colonic adenocarcinomas with a thioether-lysophospholipid derivative in mono- and combination chemotherapy.

Authors:  M E Heim; M Swoboda; W Pahlke; L Edler; U Bicker
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553

6.  Experimental colorectal cancer as a model of human disease.

Authors:  J M Gilbert
Journal:  Ann R Coll Surg Engl       Date:  1987-03       Impact factor: 1.891

7.  Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.

Authors:  I Wagner; M Habs; D Schmähl; H Amberger; U Bachmann
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

8.  Carcinogenicity of acetoxymethyl-methyl-nitrosamine after subcutaneous, intravenous and intrarectal applications in rats.

Authors:  M Habs; D Schmähl; M Wiessler
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1978-05-31

9.  Chemotherapy of chemically-induced colorectal tumours.

Authors:  J M Gilbert; E M Thompson; G Slavin; A E Kark
Journal:  J R Soc Med       Date:  1983-06       Impact factor: 5.344

10.  Alkyl phosphocholines: toxicity and anticancer properties.

Authors:  C Muschiol; M R Berger; B Schuler; H R Scherf; F T Garzon; W J Zeller; C Unger; H J Eibl; D Schmähl
Journal:  Lipids       Date:  1987-11       Impact factor: 1.880
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