Literature DB >> 6844925

DNA methylation decreases in aging but not in immortal cells.

V L Wilson, P A Jones.   

Abstract

When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.

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Year:  1983        PMID： 6844925     DOI： 10.1126/science.6844925

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  160 in total

1.  Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function.

Authors:  Weiliang Qiu; Andrea Baccarelli; Vincent J Carey; Nadia Boutaoui; Helene Bacherman; Barbara Klanderman; Stephen Rennard; Alvar Agusti; Wayne Anderson; David A Lomas; Dawn L DeMeo
Journal:  Am J Respir Crit Care Med       Date:  2011-12-08       Impact factor: 21.405

2.  Global heterochromatin loss: a unifying theory of aging?

Authors:  Amy Tsurumi; Willis X Li
Journal:  Epigenetics       Date:  2012-07-01       Impact factor: 4.528

3.  DNA methylation screening identifies driver epigenetic events of cancer cell survival.

Authors:  Daniel D De Carvalho; Shikhar Sharma; Jueng Soo You; Sheng-Fang Su; Phillippa C Taberlay; Theresa K Kelly; Xiaojing Yang; Gangning Liang; Peter A Jones
Journal:  Cancer Cell       Date:  2012-05-15       Impact factor: 31.743

Review 4.  Epigenetic programming and risk: the birthplace of cardiovascular disease?

Authors:  Maria Cristina Vinci; Gianluca Polvani; Maurizio Pesce
Journal:  Stem Cell Rev Rep       Date:  2013-06       Impact factor: 5.739

Review 5.  Epigenetic alterations in aging.

Authors:  Susana Gonzalo
Journal:  J Appl Physiol (1985)       Date:  2010-05-06

Review 6.  Epigenetic control of aging.

Authors:  Ursula Muñoz-Najar; John M Sedivy
Journal:  Antioxid Redox Signal       Date:  2010-11-22       Impact factor: 8.401

Review 7.  Higher-order genome organization in human disease.

Authors:  Tom Misteli
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-06-30       Impact factor: 10.005

8.  Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.

Authors:  Aditi Qamra; Tsz Wai Chu; Mélanie Criqui; Monika Sharma; Julissa Tsao; Danielle A Henry; Dalia Barsyte-Lovejoy; Cheryl H Arrowsmith; Neil Winegarden; Mathieu Lupien; Lea Harrington
Journal:  Elife       Date:  2020-04-16       Impact factor: 8.140

Review 9.  Age-related cataracts: Role of unfolded protein response, Ca2+ mobilization, epigenetic DNA modifications, and loss of Nrf2/Keap1 dependent cytoprotection.

Authors:  Palsamy Periyasamy; Toshimichi Shinohara
Journal:  Prog Retin Eye Res       Date:  2017-08-31       Impact factor: 21.198

Review 10.  The role of DNA methylation in aging, rejuvenation, and age-related disease.

Authors:  Adiv A Johnson; Kemal Akman; Stuart R G Calimport; Daniel Wuttke; Alexandra Stolzing; João Pedro de Magalhães
Journal:  Rejuvenation Res       Date:  2012-10       Impact factor: 4.663
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