Literature DB >> 6795629

Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants.

D Faustman, V Hauptfeld, P Lacy, J Davie.   

Abstract

Islets of Langerhans treated with donor-specific anti-Ia serum and complement were transplanted across a major histocompatibility barrier into nonimmunosuppressed diabetic mice. The allografts survived in all recipients for at least 200 days after transplantation. Rejection of an established allograft could be induced by intravenous injection of donor splenocytes. This demonstrates that allografts can serve as targets for immune rejection and supports the possible role of Ia-positive passenger lymphoid cells in initiation of immune rejection. The results show that immunosuppression of the recipient is not a prerequisite for successful transplantation.

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Year:  1981        PMID： 6795629      PMCID： PMC320354          DOI： 10.1073/pnas.78.8.5156

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  The expression of Ia antigens on immunocompetent cells in the guinea pig. II. Ia antigens on macrophages.

Authors:  U Yamashita; E M Shevach
Journal:  J Immunol       Date:  1977-11       Impact factor: 5.422

2.  Thyroid allograft immunogenicity is reduced after a period in organ culture.

Authors:  K J Lafferty; M A Cooley; J Woolnough; K Z Walker
Journal:  Science       Date:  1975-04-18       Impact factor: 47.728

3.  Collaboration between in vivo responses to LD and SD antigens of major histocompatibility complex.

Authors:  H W Sollinger; F H Bach
Journal:  Nature       Date:  1976-02-12       Impact factor: 49.962

4.  In vivo immune responses of mice during carcinogenesis by ultraviolet irradiation.

Authors:  M L Kripke; J S Lofgreen; J Beard; J M Jessup; M S Fisher
Journal:  J Natl Cancer Inst       Date:  1977-10       Impact factor: 13.506

5.  The I region transplantation antigens: immunogenicity and enhancement.

Authors:  I F McKenzie; M M Henning
Journal:  J Immunogenet       Date:  1977-08

6.  Method for the isolation of intact islets of Langerhans from the rat pancreas.

Authors:  P E Lacy; M Kostianovsky
Journal:  Diabetes       Date:  1967-01       Impact factor: 9.461

Review 7.  A cardinal role for I-region antigens (Ia) in immunological enhancement, and the clinical implications.

Authors:  D A Davies; N A Staines
Journal:  Transplant Rev       Date:  1976

8.  Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats.

Authors:  C B Kemp; M J Knight; D W Scharp; W F Ballinger; P E Lacy
Journal:  Diabetologia       Date:  1973-12       Impact factor: 10.122

9.  Serological analysis of a recombination in the H-2 region of the mouse.

Authors:  D C Shreffler; D B Amos; R Mark
Journal:  Transplantation       Date:  1966-05       Impact factor: 4.939

10.  Inhibition of immune responses in vitro by specific antiserums to Ia antigens.

Authors:  J A Frelinger; J E Niederhuber; D C Shreffler
Journal:  Science       Date:  1975-04-18       Impact factor: 47.728
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  38 in total

Review 1.  Cell migration, chimerism, and graft acceptance.

Authors:  T E Starzl; A J Demetris; N Murase; S Ildstad; C Ricordi; M Trucco
Journal:  Lancet       Date:  1992-06-27       Impact factor: 79.321

2.  Genetic control of rat heart allograft rejection: effect of different MHC and non-MHC incompatibilities.

Authors:  J Klempnauer; B Steiniger; R Lück; E Günther
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

3.  The in-vitro inhibition of rat alloantigen presentation by immunotoxins--implications for allografting.

Authors:  K N Wiley; A Clark; M Fox
Journal:  Clin Exp Immunol       Date:  1989-04       Impact factor: 4.330

4.  CD8(+) T cells resistant to costimulatory blockade are controlled by an antagonist interleukin-15/Fc protein.

Authors:  Sylvie Ferrari-Lacraz; Xin Xiao Zheng; Alberto Sanchez Fueyo; Wlodzimierz Maslinski; Thomas Moll; Terry B Strom
Journal:  Transplantation       Date:  2006-12-15       Impact factor: 4.939

5.  Islet xenografts in fully xenogeneic (rat----mouse) chimeras: evidence for normal regulation of function in a xenogeneic mouse environment.

Authors:  C Ricordi; Y Zeng; P B Carroll; H L Rilo; D R Beretier; T E Starzl; S T Ildstad
Journal:  Surgery       Date:  1992-08       Impact factor: 3.982

Review 6.  Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.

Authors:  Xiaolun Huang; Daniel J Moore; Robert J Ketchum; Craig S Nunemaker; Boris Kovatchev; Anthony L McCall; Kenneth L Brayman
Journal:  Endocr Rev       Date:  2008-07-29       Impact factor: 19.871

7.  Clinical intestinal transplantation: new perspectives and immunologic considerations.

Authors:  K Abu-Elmagd; J Reyes; S Todo; A Rao; R Lee; W Irish; H Furukawa; J Bueno; J McMichael; A T Fawzy; N Murase; J Demetris; J Rakela; J J Fung; T E Starzl
Journal:  J Am Coll Surg       Date:  1998-05       Impact factor: 6.113

8.  Prolongation of rat renal allograft survival time by donor pretreatment with 8-methoxypsoralen and longwave ultraviolet irradiation of the graft (PUVA therapy).

Authors:  H Oesterwitz; D Scholz; J Kaden; M Mebel
Journal:  Urol Res       Date:  1985

9.  One hundred pancreas transplants at a single institution.

Authors:  D E Sutherland; F C Goetz; J S Najarian
Journal:  Ann Surg       Date:  1984-10       Impact factor: 12.969

10.  Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody.

Authors:  D L Faustman; R M Steinman; H M Gebel; V Hauptfeld; J M Davie; P E Lacy
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205
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