Literature DB >> 3892843

Prolongation of rat renal allograft survival time by donor pretreatment with 8-methoxypsoralen and longwave ultraviolet irradiation of the graft (PUVA therapy).

H Oesterwitz, D Scholz, J Kaden, M Mebel.   

Abstract

Pretreatment of the kidney donor with 8-methoxypsoralen (8-MOP) and ex vivo longwave ultraviolet irradiation (UVA) of the kidney prolonged the subsequent survival on allogeneic recipients. The efficacy of this treatment seems to be dependent on the time and dose of UVA irradiation rather than on the dose of 8-MOP. In conclusion, PUVA treatment is effective in reducing the immunogenicity of the rat kidney allograft, although the mechanism remains unclear. These experimental findings are new and preliminary results in clinical human kidney transplantation are favourable.

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Year:  1985        PMID： 3892843     DOI： 10.1007/bf00261574

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  17 in total

1.  Generation of T memory cells in one-way mixed lymphocyte culture. IV. Primary and secondary responses to soluble and insoluble membrane preparations and to ultraviolet-light-inactivated stimulator cells.

Authors:  P Häyry; L C Anderson
Journal:  Scand J Immunol       Date:  1976       Impact factor: 3.487

2.  Allogeneic stimulation modulates the in vitro response of T cells to transplantation antigen.

Authors:  K J Lafferty; I S Misko; M A Cooley
Journal:  Nature       Date:  1974-05-17       Impact factor: 49.962

3.  Prolongation of the survival of skin grafts in mice by PUVA treatment.

Authors:  S Gruner; C Riese; S Schnitzler; H Meffert; E Karasek
Journal:  Experientia       Date:  1984-05-15

4.  Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells.

Authors:  D Faustman; P Lacy; J Davie; V Hauptfeld
Journal:  Science       Date:  1982-07-09       Impact factor: 47.728

5.  Orthotopic kidney transplantation in the rat with non-splinted end-to-end ureteric anastomosis: details of a technique.

Authors:  H Oesterwitz; P Althaus
Journal:  Urol Res       Date:  1982

6.  Pancreatic islet transplantation: immuno-alteration with ultraviolet irradiation.

Authors:  M A Hardy; H T Lau; C Weber; K Reemtsma
Journal:  World J Surg       Date:  1984-04       Impact factor: 3.352

7.  Molecular signals in antigen presentation. I. Effects of interleukin 1 and 2 on radiation-treated antigen-presenting cells in vivo and in vitro.

Authors:  A Tominaga; S Lefort; S B Mizel; J T Dambrauskas; R Granstein; A Lowy; B Benacerraf; M I Greene
Journal:  Clin Immunol Immunopathol       Date:  1983-11

8.  [Passive enhancement of allogeneic rat kidney transplants with antibodies against nylon-adhering splenic lymphocytes].

Authors:  J Kaden; J Groth; H Oesterwitz; K Schröder
Journal:  Z Urol Nephrol       Date:  1983-06

9.  [Humoral immune response, concentration of selected serum proteins and transplant histology following allogeneic kidney transplantation in the rat].

Authors:  J Kaden; H Oesterwitz; J Groth; R Schade; W Schneider; K Schröder
Journal:  Z Urol Nephrol       Date:  1984-08

10.  Impairment of antigen-presenting cell function by ultraviolet radiation. II. Effect of in vitro ultraviolet irradiation on antigen-presenting cells.

Authors:  I J Fox; M S Sy; B Benacerraf; M I Greene
Journal:  Transplantation       Date:  1981-04       Impact factor: 4.939
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  5 in total

1.  Photochemical donor pretreatment in clinical kidney transplantation--preliminary report.

Authors:  H Oesterwitz; D Scholz; J Kaden; G May; M Mebel; R Schirrow; W Blank
Journal:  Urol Res       Date:  1987

2.  Reduced immunogenicity of rat renal allografts after photochemical donor pretreatment and passive transfer of graft protection.

Authors:  H Oesterwitz; J Kaden; W Schneider
Journal:  Urol Res       Date:  1987

3.  Effects of photochemical donor pretreatment on the pattern of dog renal allograft infiltrating cells.

Authors:  J Kaden; H Oesterwitz; R Schirrow
Journal:  Urol Res       Date:  1989

4.  Synergistic effect of donor pretreatment with 8-methoxypsoralen and ultraviolet irradiation of the graft plus azathioprine and prednisolone therapy in prolonging rat renal allograft survival.

Authors:  H Oesterwitz; J Kaden; D Scholz; H Mrochen; M Mebel
Journal:  Urol Res       Date:  1986

5.  Failure to prolong rat renal allograft survival time by photochemical donor kidney pretreatment during hypothermic pulsatile kidney preservation.

Authors:  H Oesterwitz; J Kaden; W Schneider; W Fritsch
Journal:  Urol Res       Date:  1988
  5 in total

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