Literature DB >> 6774948

Chromosome segregation and expression of rat immunoglobulins in rat/mouse hybrid myelomas.

J Schröder, K Autio, J M Jarvis, C Milstein.   

Abstract

The chromosome segregation of hybrid myelomas from a fusion of rat immunized spleen cells and the mouse myeloma P3-X63-Ag8 has been analysed. Chromosome loss appears to be nonrandom. Most mouse chromosomes are retained. The rat chromosome are preferentially lost but a few--particularly 1-5 and 13--are rarely lost. The specific retention of some rat chromosomes explains the stability of rat Ig expression in mouse-rat hybrids. Correlation of chromosome loss and retention and loss of rat heavy and light chains leads us to propose chromosome 14 as coding for the heavy chain.

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Year:  1980        PMID： 6774948     DOI： 10.1007/bf01561561

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  11 in total

1.  Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.

Authors:  H Hengartner; T Meo; E Müller
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

2.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

3.  Letter: Fusion of two immunoglobulin-producing myeloma cells.

Authors:  R G Cotton; C Milstein
Journal:  Nature       Date:  1973-07-06       Impact factor: 49.962

Review 4.  Monoclonal antibodies as tools to analyze the serological and genetic complexities of major transplantation antigens.

Authors:  J C Howard; G W Butcher; G Galfrè; C Milstein; C P Milstein
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

5.  A rapid banding technique for human chromosomes.

Authors:  M Seabright
Journal:  Lancet       Date:  1971-10-30       Impact factor: 79.321

6.  Fusion between immunoglobulin-secreting and nonsecreting myeloma cell lines.

Authors:  G Köhler; S C Howe; C Milstein
Journal:  Eur J Immunol       Date:  1976-04       Impact factor: 5.532

7.  Somatic cell genetics of antibody-secreting cells: studies of clonal diversification and analysis by cell fusion.

Authors:  C Milstein; K Adetugbo; N J Cowan; G Köhler; D S Secher; C D Wilde
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

8.  Assignment of the gene locus for human alpha-L-fucosidase to chromosome 1 by analysis of somatic cell hybrids.

Authors:  B M Turner; M Smith; V S Turner; R S Kucherlapati; F H Ruddle; K Hirschhorn
Journal:  Somatic Cell Genet       Date:  1978-01

9.  Location of the genes for human heavy chain immunoglobulin to chromosome 6.

Authors:  M Smith; K Hirschhorn
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

10.  Assignment of the genes for triose phosphate isomerase to chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by somatic cell hybridization.

Authors:  L A Leinwand; C A Kozak; F H Ruddle
Journal:  Somatic Cell Genet       Date:  1978-03
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  3 in total

1.  Localization of the rat immunoglobulin heavy chain locus to chromosome 6.

Authors:  W S Pear; G Wahlström; J Szpirer; G Levan; G Klein; J Sümegi
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

2.  Early phase karyotype analysis of chromosome segregation after formation of mouse-mouse hybridomas with chromosome painting probes.

Authors:  L Wollweber; H Münster; S Hoffmann; K Siller; K O Greulich
Journal:  Chromosome Res       Date:  2000       Impact factor: 5.239

3.  A rat genetic linkage map and comparative maps for mouse or human homologous rat genes.

Authors:  J Yamada; T Kuramoto; T Serikawa
Journal:  Mamm Genome       Date:  1994-02       Impact factor: 2.957
  3 in total

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