Literature DB >> 628884

Assignment of the gene locus for human alpha-L-fucosidase to chromosome 1 by analysis of somatic cell hybrids.

B M Turner, M Smith, V S Turner, R S Kucherlapati, F H Ruddle, K Hirschhorn.   

Abstract

The alpha-L-fucosidases (EC 3.2.1.51) from human and mouse cells could be separated by isoelectric focusing of neuraminidase-treated cell extracts in acrylamide slab gels. Fourteen hybrid clones derived from the fusion of mouse and human cultured fibroblasts and 37 hybrid clones derived from the fusion of human long-term lymphoid lines with mouse RAG cells were tested for expression of human alpha-L-fucosidase. A strong correlation between the expression of the human enzyme and the presence or absence of human chromosome 1 was found. The presence of human alpha-L-fucosidase in clones scored as positive by isoelectric focusing was confirmed by Ouchterlony double immunodiffusion against IgG from rabbits immunized with purified human alpha-L-fucosidase. It is concluded that the structural gene locus for human alpha-L-fucosidase is located on chromosome 1.

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Year:  1978        PMID： 628884     DOI： 10.1007/bf01546492

Source DB:  PubMed          Journal:  Somatic Cell Genet        ISSN： 0098-0366


  11 in total

1.  Identification of a mutation in the structural alpha-L-fucosidase gene in fucosidosis.

Authors:  P J Willems; J K Darby; R A DiCioccio; P Nakashima; C Eng; K A Kretz; L L Cavalli-Sforza; E M Shooter; J S O'Brien
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

2.  An alpha-fucosidase pseudogene on human chromosome 2.

Authors:  B Carritt; H M Welch
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

3.  Molecular cloning of a cDNA for human alpha-L-fucosidase.

Authors:  H Fukushima; J R de Wet; J S O'Brien
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

4.  Restriction analysis of the structural alpha-L-fucosidase gene and its linkage to fucosidosis.

Authors:  J K Darby; P J Willems; P Nakashima; J Johnsen; R E Ferrell; E M Wijsman; D S Gerhard; N C Dracopoli; D Housman; J Henke
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

5.  Human lysosomal genes: arylsulfatase A and beta-galactosidase.

Authors:  G A Bruns; B J Mintz; A C Leary; V M Regina; P S Gerald
Journal:  Biochem Genet       Date:  1979-12       Impact factor: 1.890

6.  Heterogeneity of mRNA expression in Italian fucosidosis patients.

Authors:  S Guazzi; P Persici; R Gatti; P Durand; J S O'Brien; G Romeo
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

7.  Biosynthesis, processing, and extracellular release of alpha-L-fucosidase in lymphoid cell lines of different genetic origins.

Authors:  R A DiCioccio; K S Brown
Journal:  Biochem Genet       Date:  1988-06       Impact factor: 1.890

Review 8.  Chromosome 1 in relation to human disease.

Authors:  S Povey; J M Parrington
Journal:  J Med Genet       Date:  1986-04       Impact factor: 6.318

9.  A gene regulating the time dependence of alpha-L-fucosidase concentration is closely linked with the structural gene in man.

Authors:  B Tümmler; M Duthie; M Buchwald; J R Riordan
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

10.  Specific activity of alpha-L-fucosidase in sera with phenotypes of either low, intermediate, or high total enzyme activity and in a fucosidosis serum.

Authors:  R A DiCioccio; J J Barlow; K L Matta
Journal:  Biochem Genet       Date:  1986-02       Impact factor: 1.890
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