Estimates of essential neural elements for stimulation through a cochlear prosthesis.

Electrical stimulation of afferent auditory pathways through electrodes placed within and outside of the cochlea were used to study stimulation and design parameters relevant to a cochlear prosthesis. In the acute guinea pig preparation, the tract response evoked in brachium of the inferior colliculus by electrical stimulation to an ear provided estimates of the effectiveness of various electrode placements. Stimulation between an electrode in the cochlea and a site along the eighth nerve was characterized by the lowest thresholds. Stimulation between intracochlear electrodes was somewhat less effective, and stimulation between external electrodes at the nerve, cochlear nucleus, or distant point was least effective. Thresholds, expressed as current, rose at approximately 6 dB per octave for stimulus frequencies from 1 kHz to 16 kHz. Thresholds below 10 microA rms were seen for optimal placements. These observations suggest that the neural elements being stimulated are the cell bodies of the spiral ganglion cells.