Literature DB >> 6726613

A method to potentiate enteral absorption of interferon and selective delivery into lymphatics.

H Yoshikawa, K Takada, S Muranishi, Y Satoh, N Naruse.   

Abstract

The potentiated absorption of human fibroblast interferon (HuIFN-beta) with the aid of lipid-surfactant mixed micelles from the rat large intestine and lymphatic delivery were studied. The administration of HuIFN-beta with saline solution alone into the lumen of the large intestine indicated no detectable HuIFN-beta in the serum or the lymph for 5 h. Neither lipid (linoleic acid) nor surfactant ( HCO60 , polyoxyethylene hardened castor oil derivative) could promote the absorption of HuIFN-beta. However, the administration with linoleic acid- HCO60 mixed micelles enabled the great absorption of HuIFN-beta from the large intestine, and HuIFN-beta was delivered into the lymphatics with an extremely high selectivity.

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Year:  1984        PMID： 6726613     DOI： 10.1248/bpb1978.7.59

Source DB:  PubMed          Journal:  J Pharmacobiodyn        ISSN： 0386-846X


  7 in total

1.  Recombinant human interferon alpha-2a: delivery to lymphoid tissue by selected modes of application.

Authors:  A Supersaxo; W Hein; H Gallati; H Steffen
Journal:  Pharm Res       Date:  1988-08       Impact factor: 4.200

2.  Effect of recombinant mouse interferon-beta on acute and latent herpes simplex infection in mice.

Authors:  M Yamada; Y Arao; A Hatano; F Uno; S Nii
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

3.  Bile salt-fatty acid mixed micelles as nasal absorption promoters of peptides. I. Effects of ionic strength, adjuvant composition, and lipid structure on the nasal absorption of [D-Arg2]kyotorphin.

Authors:  P Tengamnuay; A K Mitra
Journal:  Pharm Res       Date:  1990-02       Impact factor: 4.200

4.  Potentiation of enteral absorption of human interferon alpha and selective transfer into lymphatics in rats.

Authors:  H Yoshikawa; K Takada; Y Satoh; N Naruse; S Muranishi
Journal:  Pharm Res       Date:  1985-09       Impact factor: 4.200

5.  Enhanced selective lymphatic delivery of cyclosporin a by solubilizers and intensified immunosuppressive activity against mice skin allograft.

Authors:  K Takada; H Yoshimura; H Yoshikawa; S Muranishi; T Yasumura; T Oka
Journal:  Pharm Res       Date:  1986-02       Impact factor: 4.200

6.  Effect of oleic Acid vesicles on intestinal absorption of carboxyfluorescein in rats.

Authors:  M Murakami; H Yoshikawa; K Takada; S Muranishi
Journal:  Pharm Res       Date:  1986-02       Impact factor: 4.200

7.  Development of Interferon Suppositories. I. Enhanced Rectal Absorption of Human Fibroblast Interferon by Fusogenic Lipid via Lymphotropic Delivery in Rats.

Authors:  H Yoshikawa; K Takada; Y Satoh; N Naruse; S Muranishi
Journal:  Pharm Res       Date:  1986-04       Impact factor: 4.200
  7 in total

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