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Literature DB >> 24271354

Effect of oleic Acid vesicles on intestinal absorption of carboxyfluorescein in rats.

M Murakami¹, H Yoshikawa, K Takada, S Muranishi.

Abstract

The effect of oleic acid vesicles (ufasomes) on the intestinal absorption of entrapped carboxyfluo-rescein (CF) was investigated by an in situ closed-loop method in rats. Entrapment of CF in ufasomes enhanced the absorption of CF at the earlier stage following intraduodenal administration, and the threshold concentration of the fatty acid for promoting the absorption of CF was approximately 8 mM. The absorption of CF from the large intestine was promoted much more effectively than from the small intestine. These studies suggest that ufasomes have potential as carriers for the oral administration of poorly absorbable drugs.

Entities: Chemical Species

Year: 1986 PMID： 24271354 DOI： 10.1023/A:1016368714631

Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200

15 in total

4. Ufasomes Mediated Cutaneous Delivery of Dexamethasone: Formulation and Evaluation of Anti-Inflammatory Activity by Carrageenin-Induced Rat Paw Edema Model.

Authors: Rajkamal Mittal; Arvind Sharma; Sandeep Arora
Journal: J Pharm (Cairo) Date: 2012-11-25

4 in total

Effect of oleic Acid vesicles on intestinal absorption of carboxyfluorescein in rats.

1. Oral administration of insulin by encapsulation within liposomes.

2. A quantitative relationship between permeability and the degree of peroxidation in ufasome membranes.

3. Ufasomes are stable particles surrounded by unsaturated fatty acid membranes.

4. Liposome-cell interaction: transfer and intracellular release of a trapped fluorescent marker.

5. A method to potentiate enteral absorption of interferon and selective delivery into lymphatics.

Review 6. Characteristics of drug absorption via the rectal route.

7. Preparation and properties of vesicles enclosed by fatty acid membranes.

8. Oral treatment of haemophilia A by gastrointestinal absorption of factor VIII entrapped in liposomes.

9. Effect of fatty acids and monoglycerides on permeability of lipid bilayer.

10. Transmucosal passage of liposomally-entrapped drugs in rat small intestine.

1. Formulation and in vitro evaluation of ufasomes for dermal administration of methotrexate.

2. Insight into carbon quantum dot-vesicles interactions: role of functional groups.

3. Lipoidal soft hybrid biocarriers of supramolecular construction for drug delivery.

4. Ufasomes Mediated Cutaneous Delivery of Dexamethasone: Formulation and Evaluation of Anti-Inflammatory Activity by Carrageenin-Induced Rat Paw Edema Model.