Literature DB >> 24272847

Potentiation of enteral absorption of human interferon alpha and selective transfer into lymphatics in rats.

H Yoshikawa1, K Takada, Y Satoh, N Naruse, S Muranishi.   

Abstract

Enhancement of human leucocyte interferon (HuIFN-α) absorption from rat large intestine was studied with the aid of lipid, surfactant and lipid-surfactant mixed micelles. Neither the emulsified lipid (linoleic acid) nor the surfactant (HCO60, polyoxyethylated [60 moles] hydrogenated castor oil) alone were able to enhance the absorption of HuIFN-α. However, linoleic acid-HCO60 mixed micelles enhanced the absorption of HuIFN-α from the large intestine. Highly selective delivery of HuIFN-α into the lymphatics compared to the blood was also observed.

Entities:  

Year:  1985        PMID： 24272847     DOI： 10.1023/A:1016377114477

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  6 in total

1.  Potential absorption of heparin from the small intestine and the large intestine in the presence of monoolein mixed micelles.

Authors:  S Muranishi; Y Tokunaga; K Taniguchi; H Sezaki
Journal:  Chem Pharm Bull (Tokyo)       Date:  1977-05       Impact factor: 1.645

2.  Circulating interferon in rabbits after administration of human interferon by different routes.

Authors:  K Cantell; L Pyhälä
Journal:  J Gen Virol       Date:  1973-07       Impact factor: 3.891

3.  A method to potentiate enteral absorption of interferon and selective delivery into lymphatics.

Authors:  H Yoshikawa; K Takada; S Muranishi; Y Satoh; N Naruse
Journal:  J Pharmacobiodyn       Date:  1984-01

4.  Comparison of disappearance from blood and lymphatic delivery of human fibroblast interferon in rat by different administration routes.

Authors:  H Yoshikawa; Y Satoh; N Naruse; K Takada; S Muranishi
Journal:  J Pharmacobiodyn       Date:  1985-03

5.  Pharmacokinetics of human interferon-beta in monkeys.

Authors:  J Hilfenhaus; H Damm; T Hofstaetter; R Mauler; H Ronneberger; E Weinmann
Journal:  J Interferon Res       Date:  1981

6.  Human fibroblast interferon for clinical trials: pharmacokinetics and tolerability in experimental animals and humans.

Authors:  A Billiau; P De Somers; V G Edy; E De Clercq; H Heremans
Journal:  Antimicrob Agents Chemother       Date:  1979-07       Impact factor: 5.191
  6 in total
  2 in total

1.  Recombinant human interferon alpha-2a: delivery to lymphoid tissue by selected modes of application.

Authors:  A Supersaxo; W Hein; H Gallati; H Steffen
Journal:  Pharm Res       Date:  1988-08       Impact factor: 4.200

2.  Development of Interferon Suppositories. I. Enhanced Rectal Absorption of Human Fibroblast Interferon by Fusogenic Lipid via Lymphotropic Delivery in Rats.

Authors:  H Yoshikawa; K Takada; Y Satoh; N Naruse; S Muranishi
Journal:  Pharm Res       Date:  1986-04       Impact factor: 4.200
  2 in total

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