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Literature DB >> 6695923

Isolation of repetitive DNA sequences from human chromosome 21.

Abstract

We have developed a method for the isolation of phage from the human genomic library that carry repetitive DNA sequences highly represented on specific human chromosomes. We have used this technique to select recombinants carrying inserts concentrated on chromosome 21. Five clones, representing two families of sequences, have been characterized. Members of each family show cross-homology, but the two families show no homology with each other. In all but one case, the clones do not contain members of the human Alu repeat family. Single chromosome-concentrated repetitive sequences should prove to be useful in studies of the origin, evolution, and function of repetitive DNA and in regional chromosome mapping.

Entities: Species

Mesh：

Substances：
DNA, Recombinant
DNA

Year: 1984 PMID： 6695923 PMCID： PMC1684372

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

32 in total

1. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

2. Screening lambdagt recombinant clones by hybridization to single plaques in situ.

Authors: W D Benton; R W Davis
Journal: Science Date: 1977-04-08 Impact factor: 47.728

3. Gene regulation for higher cells: a theory.

Authors: R J Britten; E H Davidson
Journal: Science Date: 1969-07-25 Impact factor: 47.728

4. The organization of repetitive sequences in mammalian globin gene clusters.

Authors: E F Fritsch; C K Shen; R M Lawn; T Maniatis
Journal: Cold Spring Harb Symp Quant Biol Date: 1981

5. Repeated sequence specific to human males.

Authors: H Cooke
Journal: Nature Date: 1976-07-15 Impact factor: 49.962

6. Genetic fine-structure mapping in human chromosome 11 by use of repetitive DNA sequences.

Authors: J F Gusella; C Jones; F T Kao; D Housman; T T Puck
Journal: Proc Natl Acad Sci U S A Date: 1982-12 Impact factor: 11.205

7. Partial nucleotide sequence of the 300-nucleotide interspersed repeated human DNA sequences.

Authors: C M Rubin; C M Houck; P L Deininger; T Friedmann; C W Schmid
Journal: Nature Date: 1980-03-27 Impact factor: 49.962

8. A new method of in situ hybridization.

Authors: J E Manning; N D Hershey; T R Broker; M Pellegrini; H K Mitchell; N Davidson
Journal: Chromosoma Date: 1975-11-24 Impact factor: 4.316

9. Ubiquitous, interspersed repeated sequences in mammalian genomes.

Authors: W R Jelinek; T P Toomey; L Leinwand; C H Duncan; P A Biro; P V Choudary; S M Weissman; C M Rubin; C M Houck; P L Deininger; C W Schmid
Journal: Proc Natl Acad Sci U S A Date: 1980-03 Impact factor: 11.205

10. Presence of a highly repetitive and widely dispersed DNA sequence in the human genome.

Authors: M Tashima; B Calabretta; G Torelli; M Scofield; A Maizel; G F Saunders
Journal: Proc Natl Acad Sci U S A Date: 1981-03 Impact factor: 11.205

7 in total

Review 1. Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".

Authors: P Vogt
Journal: Hum Genet Date: 1990-03 Impact factor: 4.132

Isolation of repetitive DNA sequences from human chromosome 21.

1. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

2. Screening lambdagt recombinant clones by hybridization to single plaques in situ.

3. Gene regulation for higher cells: a theory.

4. The organization of repetitive sequences in mammalian globin gene clusters.

5. Repeated sequence specific to human males.

6. Genetic fine-structure mapping in human chromosome 11 by use of repetitive DNA sequences.

7. Partial nucleotide sequence of the 300-nucleotide interspersed repeated human DNA sequences.

8. A new method of in situ hybridization.

9. Ubiquitous, interspersed repeated sequences in mammalian genomes.

10. Presence of a highly repetitive and widely dispersed DNA sequence in the human genome.

Review 1. Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".

2. Repeated DNA sequences in the distal long arm of the human X chromosome.

3. Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

4. Chromosomal localization of several families of repetitive sequences by in situ hybridization.

5. Human chromosome-specific repetitive DNA sequences: novel markers for genetic analysis.

6. Translocation and amplification of an X-chromosome DNA repeat in inbred strains of mice.

7. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization.