Literature DB >> 3014865

Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

M L Van Keuren, P C Watkins, H A Drabkin, E W Jabs, J F Gusella, D Patterson.   

Abstract

We have used a panel of Chinese hamster X human somatic cell hybrids, each containing various portions of chromosome 21 as the only detectable human chromosome component, for regional mapping of cloned, chromosome 21-derived DNA sequences. Thirty unique and very low-repeat sequences were mapped to the short arm and three sections of the long arm. Three unique sequences map to the proximal part of the terminal band 21q22.3, and five to the distal part of this band. Some of these may represent parts of gene sequences that may be relevant to the pathogenesis of Down syndrome, as 21q22 is the area required to be present in triplicate for the full clinical picture.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3014865      PMCID： PMC1684850     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  54 in total

1.  Cardiac malformation in mongolism: a prospective study of 184 mongoloid children.

Authors:  R D ROWE; I A UCHIDA
Journal:  Am J Med       Date:  1961-11       Impact factor: 4.965

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  [Overactivity of the indophenol oxidase (form dimeric) in the trisomy 21, secondary to triplicated gene (author's transl)].

Authors:  S Sichitiu; P M Sinet; J Lejeune; J Frézal
Journal:  Humangenetik       Date:  1974-06-26

Review 4.  Induction and isolation of auxotrophic mutants in mammalian cells.

Authors:  F T Kao; T T Puck
Journal:  Methods Cell Biol       Date:  1974       Impact factor: 1.441

5.  Presenile dementia and Alzheimer's disease in mongolism.

Authors:  M I Olson; C M Shaw
Journal:  Brain       Date:  1969-03       Impact factor: 13.501

6.  Presenile dementia in Down's syndrome. Ultrastructural identity with Alzheimer's disease.

Authors:  W G Ellis; J R McCulloch; C L Corley
Journal:  Neurology       Date:  1974-02       Impact factor: 9.910

7.  Down's syndrome. The possibility of a pathogenetic segment on chromosome no. 21.

Authors:  E Niebuhr
Journal:  Humangenetik       Date:  1974-01-22

8.  Cardiac malformations associated with Down's syndrome.

Authors:  R Tandon; J E Edwards
Journal:  Circulation       Date:  1973-06       Impact factor: 29.690

9.  Familial Down syndrome due to t(10;21) translocation: evidence that the Down phenotype is related to trisomy of a specific segment of chromosome 21.

Authors:  J D Williams; R L Summitt; P R Martens; R A Kimbrell
Journal:  Am J Hum Genet       Date:  1975-07       Impact factor: 11.025

10.  The linkage of genes for the human interferon-induced antiviral protein and indophenol oxidase-B traits to chromosome G-21.

Authors:  Y H Tan; J Tischfield; F H Ruddle
Journal:  J Exp Med       Date:  1973-02-01       Impact factor: 14.307
View more
  31 in total

1.  Isolation of a yeast artificial chromosome spanning the 8;21 translocation breakpoint t(8;21)(q22;q22.3) in acute myelogenous leukemia.

Authors:  J Gao; P Erickson; K Gardiner; M M Le Beau; M O Diaz; D Patterson; J D Rowley; H A Drabkin
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

2.  Molecular mechanism in the formation of a human ring chromosome 21.

Authors:  C Wong; H H Kazazian; G Stetten; W C Earnshaw; M L Van Keuren; S E Antonarakis
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

3.  Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome.

Authors:  Z Rahmani; J L Blouin; N Creau-Goldberg; P C Watkins; J F Mattei; M Poissonnier; M Prieur; Z Chettouh; A Nicole; A Aurias
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

4.  Cytogenetic and molecular analysis of a de novo tandem duplication of chromosome 21.

Authors:  J L Blouin; A Aurias; N Créau-Goldberg; F Apiou; C Alcaide-Loridan; A Bruel; M Prieur; J Kraus; J M Delabar; P M Sinet
Journal:  Hum Genet       Date:  1991-12       Impact factor: 4.132

5.  Isolation, characterization, and regional mapping of microclones from a human chromosome 21 microdissection library.

Authors:  J Yu; J Hartz; Y Xu; R M Gemmill; J R Korenberg; D Patterson; F T Kao
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

6.  The COL6A1 and COL6A2 genes exist as a gene cluster and detect highly informative DNA polymorphisms in the telomeric region of human chromosome 21q.

Authors:  C A Francomano; G R Cutting; M K McCormick; M L Chu; R Timpl; H K Hong; S E Antonarakis
Journal:  Hum Genet       Date:  1991-06       Impact factor: 4.132

7.  Incidence of Down syndrome.

Authors:  M Adams; J D Erickson; P M Layde; G P Oakley
Journal:  Am J Hum Genet       Date:  1987-03       Impact factor: 11.025

8.  Isolation and characterization of wheat-rye recombinants involving chromosome arm 1DS of wheat.

Authors:  P M Rogowsky; F L Guidet; P Langridge; K W Shepherd; R M Koebner
Journal:  Theor Appl Genet       Date:  1991-10       Impact factor: 5.699

9.  A polymorphic locus [D21S144] is detected by probe pVC12 on chromosome 21.

Authors:  G Van Camp; P Stinissen; A Vandenberghe; C Van Broeckhoven
Journal:  Nucleic Acids Res       Date:  1989-06-12       Impact factor: 16.971

10.  Isolation of chromosome-21-specific DNA probes and their use in the analysis of nondisjunction in Down syndrome.

Authors:  J Galt; E Boyd; J M Connor; M A Ferguson-Smith
Journal:  Hum Genet       Date:  1989-01       Impact factor: 4.132
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.