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Literature DB >> 6262808

Presence of a highly repetitive and widely dispersed DNA sequence in the human genome.

M Tashima, B Calabretta, G Torelli, M Scofield, A Maizel, G F Saunders.

Abstract

A genomic DNA library consisting of human DNA fragments about 18 kilobases long cloned in a bacteriophage lambda vector was found to contain a specific repeated DNA segment. The repeated sequence is present in greater than 95% of the genomic library, and selected clones contain at least two copies of the sequence. Our experiments indicate that this highly repetitive sequence (approximately 400,000 copies per haploid genome) is widely distributed in the human genome and is represented in the cytoplasmic polysomal mRNA. This sequence is homologous to the 300-base-pair Alu repeat family, the predominant repeat sequence in man.

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Year: 1981 PMID： 6262808 PMCID： PMC319160 DOI： 10.1073/pnas.78.3.1508

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

1. Site specific recA--independent recombination between bacterial plasmids: involvement of palindromes at the recombinational loci.

Authors: D J Kopecko; S N Cohen
Journal: Proc Natl Acad Sci U S A Date: 1975-04 Impact factor: 11.205

2. Structural genes adjacent to interspersed repetitive DNA sequences.

Authors: E H Davidson; B R Hough; W H Klein; R J Britten
Journal: Cell Date: 1975-03 Impact factor: 41.582

3. Comparative aspects of DNA organization in Metazoa.

Authors: E H Davidson; G A Galau; R C Angerer; R J Britten
Journal: Chromosoma Date: 1975-07-21 Impact factor: 4.316

4. Double-stranded regions in heterogeneous nuclear RNA from Hela cells.

Authors: W Jelinek; J E Darnell
Journal: Proc Natl Acad Sci U S A Date: 1972-09 Impact factor: 11.205

5. Double-helical regions in nuclear precursor of mRNA (pre-mRNA).

Authors: A P Ryskov; G F Saunders; V R Farashyan; G P Georgiev
Journal: Biochim Biophys Acta Date: 1973-06-08

6. Analysis of repeating DNA sequences by reassociation.

Authors: R J Britten; D E Graham; B R Neufeld
Journal: Methods Enzymol Date: 1974 Impact factor: 1.600

7. Populations of repeated DNA sequences in the human genome.

Authors: G F Saunders; S Shirakawa; P P Saunders; F E Arrighi; T C Hsu
Journal: J Mol Biol Date: 1972-02-14 Impact factor: 5.469

8. Insulin gene expression during development of the fetal bovine pancreas.

Authors: M L Frazier; R A Montagna; G F Saunders
Journal: Biochemistry Date: 1981-01-20 Impact factor: 3.162

9. Nucleotide sequence of the rightward operator of phage lambda.

Authors: T Maniatis; A Jeffrey; D G Kleid
Journal: Proc Natl Acad Sci U S A Date: 1975-03 Impact factor: 11.205

10. Epstein-barr virus-negative human malignant T-cell lines.

Authors: J Kaplan; T C Shope; W D Peterson
Journal: J Exp Med Date: 1974-05-01 Impact factor: 14.307

29 in total

1. Distribution of interspersed repeats (Alu and Kpn) on NotI restriction fragments of human chromosome 21.

Authors: J Sainz; L Pevny; Y Wu; C R Cantor; C L Smith
Journal: Proc Natl Acad Sci U S A Date: 1992-02-01 Impact factor: 11.205

2. Enrichment of middle repetitive element Bm-1 transcripts in translationally active RNA fractions of the silkmoth, Bombyx mori.

Authors: G P Gao; R J Herrera
Journal: Genetica Date: 1996-03 Impact factor: 1.082

10. Human satellite I sequences include a male specific 2.47 kb tandemly repeated unit containing one Alu family member per repeat.

Authors: M Frommer; J Prosser; P C Vincent
Journal: Nucleic Acids Res Date: 1984-03-26 Impact factor: 16.971

Presence of a highly repetitive and widely dispersed DNA sequence in the human genome.

1. Site specific recA--independent recombination between bacterial plasmids: involvement of palindromes at the recombinational loci.

2. Structural genes adjacent to interspersed repetitive DNA sequences.

3. Comparative aspects of DNA organization in Metazoa.

4. Double-stranded regions in heterogeneous nuclear RNA from Hela cells.

5. Double-helical regions in nuclear precursor of mRNA (pre-mRNA).

6. Analysis of repeating DNA sequences by reassociation.

7. Populations of repeated DNA sequences in the human genome.

8. Insulin gene expression during development of the fetal bovine pancreas.

9. Nucleotide sequence of the rightward operator of phage lambda.

10. Epstein-barr virus-negative human malignant T-cell lines.

1. Distribution of interspersed repeats (Alu and Kpn) on NotI restriction fragments of human chromosome 21.

2. Enrichment of middle repetitive element Bm-1 transcripts in translationally active RNA fractions of the silkmoth, Bombyx mori.

3. A new repetitive element of the CR1 family downstream of the chicken vitellogenin gene.

4. Sequences homologous to the human D1S1 locus present on human chromosome 3.

5. The occurrence of families of repetitive sequences in a library of cloned cDNA from human lymphocytes.

6. mRNA in human cells contains sequences complementary to the Alu family of repeated DNA.

7. Isolation and characterization of six different chicken actin genes.

8. Differential expression of selected genes in human leukemia leukocytes.

9. The distribution of interspersed repeats is nonuniform and conserved in the mouse and human genomes.

10. Human satellite I sequences include a male specific 2.47 kb tandemly repeated unit containing one Alu family member per repeat.