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Literature DB >> 6650505

Regional localization for HLA by recombination with a fragile site at 6p23.

J C Mulley, J Hay, L J Sheffield, G R Sutherland.

Abstract

A family with a fragile site on chromosome 6 at band p23 was examined for recombination between the fragile site and HLA. Recombination was observed in four of the 20 offspring in whom it could occur. The estimate of the genetic length of chromosome between the fragile site and HLA is 20 centimorgans (cM) with a lower 95% probability limit of 8.5 cM, placing HLA proximal to the midpoint of 6p22. The most likely regional localization is at 6p21.3, which agrees closely with methods that do not involve recombination with the fragile site. This fragile site does not measurably disrupt recombination frequency, and the allele predisposing to expression of the fragile site is situated at the fragile site.

Entities: Gene

Mesh：

Substances：
HLA Antigens

Year: 1983 PMID： 6650505 PMCID： PMC1685972

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

11 in total

1. Localization of HLA on the short arm of chromosome 6.

Authors: M H Breuning; E M van den Berg-Loonen; L F Bernini; J B Bijlsma; E van Loghem; P Meera Khan; L E Nijenhuis
Journal: Hum Genet Date: 1977-06-30 Impact factor: 4.132

2. Proceedings: HL-A loci and chromosome 6.

Authors: D S Borgaonkar; W B Bias
Journal: Cytogenet Cell Genet Date: 1974

3. Segregation of genetic markers in families with chromosome polymorphisms and structural rearrangements involving chromosome 1.

Authors: P J Cook; E B Robson; K E Buckton; P A Jacobs; P E Polani
Journal: Ann Hum Genet Date: 1974-01 Impact factor: 1.670

4. Heritable fragile site on chromosome 16: probable localization of haptoglobin locus in man.

Authors: R E Magenis; F Hecht; E W Lovrien
Journal: Science Date: 1970-10-02 Impact factor: 47.728

5. Regional mapping of the HLA on the short arm of chromosome 6.

Authors: R Berger; A Bernheim; M Sasportes; G Hauptmann; J Hors; L Legrand; M Fellous
Journal: Clin Genet Date: 1979-03 Impact factor: 4.438

6. Genetic length of a human chromosomal segment measured by recombination between two fragile sites.

Authors: G R Sutherland; E Baker; J C Mulley
Journal: Science Date: 1982-07-23 Impact factor: 47.728

7. Exclusion mapping illustrated by the MNSs blood group.

Authors: P J Cook; J E Noades; C G Lomas; K E Buckton; E B Robson
Journal: Ann Hum Genet Date: 1980-07 Impact factor: 1.670

8. Partial trisomy 6p: 46,XX, -10, der(10),t(6;10) (p22;q26)pat and HLA localisation.

Authors: P Ferrando; C San Román; S Rodriguez de Cordoba; A Arnaiz-Villena
Journal: J Med Genet Date: 1981-06 Impact factor: 6.318

9. Introduction of a human X-6 translocation chromosome into a mouse teratocarcinoma: investigation of control of HLA-A, B, C expression.

Authors: P N Goodfellow; G Banting; J Trowsdale; S Chambers; E Solomon
Journal: Proc Natl Acad Sci U S A Date: 1982-02 Impact factor: 11.205

10. The 1981 catalogue of assigned human genetic markers and report of the nomenclature committee. Oslo Conference (1981): Sixth International Workshop on Human Gene Mapping.

Authors: T B Shows; P J McAlpine
Journal: Cytogenet Cell Genet Date: 1982

4 in total