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Literature DB >> 6594692

Salt-induced Z-A-Z transition sequence in the mixed ribo-deoxyribo copolymer poly(rG-dC) X poly(rG-dC).

Abstract

The left-handed helical conformation of various polynucleotides has been seen in solution at higher salt concentration than has the right-handed helical conformation of the corresponding polymer. We report here, however, studies of conformational transitions in the mixed polymer poly-(rG-dC) X poly(rG-dC). This polynucleotide appears to exist in a Z conformation under low-salt conditions, converts to an A helix at intermediate salt, and reverts to a left-handed helix at high-salt concentration.

Entities: Chemical

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Year: 1984 PMID： 6594692 PMCID： PMC392130 DOI： 10.1073/pnas.81.23.7284

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

Review 1. The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.

Authors: G S Manning
Journal: Q Rev Biophys Date: 1978-05 Impact factor: 5.318

2. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

Authors: F M Pohl; T M Jovin
Journal: J Mol Biol Date: 1972-06-28 Impact factor: 5.469

3. Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

Authors: A H Wang; G J Quigley; F J Kolpak; J L Crawford; J H van Boom; G van der Marel; A Rich
Journal: Nature Date: 1979-12-13 Impact factor: 49.962

4. High-salt d(CpGpCpG), a left-handed Z' DNA double helix.

Authors: H Drew; T Takano; S Tanaka; K Itakura; R E Dickerson
Journal: Nature Date: 1980-08-07 Impact factor: 49.962

5. "Alternating B-DNA" conformation for the oligo(dG-dC) duplex in high-salt solution.

Authors: D J Patel; L L Canuel; F M Pohl
Journal: Proc Natl Acad Sci U S A Date: 1979-06 Impact factor: 11.205

6. Left-handed double helical DNA: variations in the backbone conformation.

Authors: A J Wang; G J Quigley; F J Kolpak; G van der Marel; J H van Boom; A Rich
Journal: Science Date: 1981-01-09 Impact factor: 47.728

7. Conformation of poly(dG-dC) . poly(dG-dC) modified by the carcinogens N-acetoxy-N-acetyl-2-aminofluorene and N-hydroxy-N-2-aminofluorene.

Authors: E Sage; M Leng
Journal: Proc Natl Acad Sci U S A Date: 1980-08 Impact factor: 11.205

4. Influence of tetraalkyl ammonium ions on the structure of poly (rG-dC).poly (rG-dC): unexpected transitions among the Z, A and B conformations.

Authors: S D Jayasena; M J Behe
Journal: Nucleic Acids Res Date: 1987-05-11 Impact factor: 16.971

4 in total

Salt-induced Z-A-Z transition sequence in the mixed ribo-deoxyribo copolymer poly(rG-dC) X poly(rG-dC).

Review 1. The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.

2. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

3. Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

4. High-salt d(CpGpCpG), a left-handed Z' DNA double helix.

5. "Alternating B-DNA" conformation for the oligo(dG-dC) duplex in high-salt solution.

6. Left-handed double helical DNA: variations in the backbone conformation.

7. Conformation of poly(dG-dC) . poly(dG-dC) modified by the carcinogens N-acetoxy-N-acetyl-2-aminofluorene and N-hydroxy-N-2-aminofluorene.

8. The high salt form of poly(dG-dC).poly(dG-dC) is left-handed Z-DNA: Raman spectra of crystals and solutions.

9. Induction of the Z conformation in poly(dG-dC).poly(dG-dC) by binding of N-2-acetylaminofluorene to guanine residues.

10. Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).

1. CD of homopolymer DNA-RNA hybrid duplexes and triplexes containing A-T or A-U base pairs.

2. Salt induced transitions between multiple conformations of poly (rG-m5dC).poly (rG-m5dC).

3. New DNA polymorphism: evidence for a low salt, left-handed form of poly(dG-m5dC).

4. Influence of tetraalkyl ammonium ions on the structure of poly (rG-dC).poly (rG-dC): unexpected transitions among the Z, A and B conformations.