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Literature DB >> 6594683

A consistent picture of protein dynamics.

Abstract

Information about the protein dynamics of myoglobin obtained by x-ray and Mössbauer investigations is analyzed and compared with computer simulations. Computer simulations give correct amplitudes of mean-square displacements but fail in the description of the time dependence of motions. Our model describes protein dynamics at physiological temperatures as an overdamped diffusion-like motion in a restricted space. The fluctuations occur around the average conformation determined by x-ray structure analysis. The gain in entropy drives the molecule into the transition state and, in this way, accounts for its flexibility.

Entities: Gene

Mesh：

Substances：
Myoglobin

Year: 1984 PMID： 6594683 PMCID： PMC392082 DOI： 10.1073/pnas.81.22.7088

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. Dynamics of the aromatic amino acid residues in the globular conformation of the basic pancreatic trypsin inhibitor (BPTI). I. 1H NMR studies.

Authors: G Wagner; A DeMarco; K Wüthrich
Journal: Biophys Struct Mech Date: 1976-08-23

2. Temperature-dependent X-ray diffraction as a probe of protein structural dynamics.

Authors: H Frauenfelder; G A Petsko; D Tsernoglou
Journal: Nature Date: 1979-08-16 Impact factor: 49.962

3. Crystallographic studies of the dynamic properties of lysozyme.

Authors: P J Artymiuk; C C Blake; D E Grace; S J Oatley; D C Phillips; M J Sternberg
Journal: Nature Date: 1979-08-16 Impact factor: 49.962

Review 4. Protein conformation, dynamics, and folding by computer simulation.

Authors: M Levitt
Journal: Annu Rev Biophys Bioeng Date: 1982

Review 5. The internal dynamics of globular proteins.

Authors: M Karplus; J A McCammon
Journal: CRC Crit Rev Biochem Date: 1981

6. Protein dynamics. Mössbauer spectroscopy on deoxymyoglobin crystals.

Authors: F Parak; E W Knapp; D Kucheida
Journal: J Mol Biol Date: 1982-10-15 Impact factor: 5.469

7. Low frequency vibrations and the dynamics of proteins and polypeptides.

Authors: W L Peticolas
Journal: Methods Enzymol Date: 1979 Impact factor: 1.600

8. Computer simulation of the dynamics of hydrated protein crystals and its comparison with x-ray data.

Authors: W F van Gunsteren; H J Berendsen; J Hermans; W G Hol; J P Postma
Journal: Proc Natl Acad Sci U S A Date: 1983-07 Impact factor: 11.205

9. Dynamics of a small globular protein in terms of low-frequency vibrational modes.

Authors: N Go; T Noguti; T Nishikawa
Journal: Proc Natl Acad Sci U S A Date: 1983-06 Impact factor: 11.205

10. Dynamics of heme iron in crystals of metmyoglobin and deoxymyoglobin.

Authors: E R Bauminger; S G Cohen; I Nowik; S Ofer; J Yariv
Journal: Proc Natl Acad Sci U S A Date: 1983-02 Impact factor: 11.205

37 in total

1. Influence of static and dynamic disorder on the visible and infrared absorption spectra of carbonmonoxy horseradish peroxidase.

Authors: A D Kaposi; J M Vanderkooi; W W Wright; J Fidy; S S Stavrov
Journal: Biophys J Date: 2001-12 Impact factor: 4.033

2. Temperature dependence of protein dynamics: computer simulation analysis of neutron scattering properties.

Authors: Jennifer A Hayward; Jeremy C Smith
Journal: Biophys J Date: 2002-03 Impact factor: 4.033

3. Molecular dynamics decomposition of temperature-dependent elastic neutron scattering by a protein solution.

Authors: Jennifer A Hayward; John L Finney; Roy M Daniel; Jeremy C Smith
Journal: Biophys J Date: 2003-08 Impact factor: 4.033

4. Bulk-solvent and hydration-shell fluctuations, similar to alpha- and beta-fluctuations in glasses, control protein motions and functions.

Authors: P W Fenimore; Hans Frauenfelder; B H McMahon; R D Young
Journal: Proc Natl Acad Sci U S A Date: 2004-09-24 Impact factor: 11.205