Literature DB >> 11222106

Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method.

C Garner1, L A McInnes, S K Service, M Spesny, E Fournier, P Leon, N B Freimer.   

Abstract

Recently developed algorithms permit nonparametric linkage analysis of large, complex pedigrees with multiple inbreeding loops. We have used one such algorithm, implemented in the package SimWalk2, to reanalyze previously published genome-screen data from a Costa Rican kindred segregating for severe bipolar disorder. Our results are consistent with previous linkage findings on chromosome 18 and suggest a new locus on chromosome 5 that was not identified using traditional linkage analysis.

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Year:  2001        PMID： 11222106      PMCID： PMC1275626          DOI： 10.1086/319517

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  12 in total

1.  Allele frequency estimation from data on relatives.

Authors:  M Boehnke
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

2.  Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.

Authors:  E Sobel; K Lange
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

3.  The affected-pedigree-member method of linkage analysis.

Authors:  D E Weeks; K Lange
Journal:  Am J Hum Genet       Date:  1988-02       Impact factor: 11.025

Review 4.  Bipolar affective disorders linked to DNA markers on chromosome 11.

Authors:  J A Egeland; D S Gerhard; D L Pauls; J N Sussex; K K Kidd; C R Allen; A M Hostetter; D E Housman
Journal:  Nature       Date:  1987 Feb 26-Mar 4       Impact factor: 49.962

5.  Complete multipoint sib-pair analysis of qualitative and quantitative traits.

Authors:  L Kruglyak; E S Lander
Journal:  Am J Hum Genet       Date:  1995-08       Impact factor: 11.025

6.  Easy calculations of lod scores and genetic risks on small computers.

Authors:  G M Lathrop; J M Lalouel
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

7.  A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees.

Authors:  L A McInnes; M A Escamilla; S K Service; V I Reus; P Leon; S Silva; E Rojas; M Spesny; S Baharloo; K Blankenship; A Peterson; D Tyler; N Shimayoshi; C Tobey; S Batki; S Vinogradov; L Meza; A Gallegos; E Fournier; L B Smith; S H Barondes; L A Sandkuijl; N B Freimer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

8.  Construction of multilocus genetic linkage maps in humans.

Authors:  E S Lander; P Green
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

9.  Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23.

Authors:  N B Freimer; V I Reus; M A Escamilla; L A McInnes; M Spesny; P Leon; S K Service; L B Smith; S Silva; E Rojas; A Gallegos; L Meza; E Fournier; S Baharloo; K Blankenship; D J Tyler; S Batki; S Vinogradov; J Weissenbach; S H Barondes; L A Sandkuijl
Journal:  Nat Genet       Date:  1996-04       Impact factor: 38.330

10.  A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish.

Authors:  E I Ginns; J Ott; J A Egeland; C R Allen; C S Fann; D L Pauls; J Weissenbachoff; J P Carulli; K M Falls; T P Keith; S M Paul
Journal:  Nat Genet       Date:  1996-04       Impact factor: 38.330
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  7 in total

1.  Genomewide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method.

Authors:  N J Camp; S L Neuhausen; J Tiobech; A Polloi; H Coon; M Myles-Worsley
Journal:  Am J Hum Genet       Date:  2001-10-19       Impact factor: 11.025

2.  Gene-environment interplay in affect and dementia: emotional modulation of cognitive expression in personal outcomes.

Authors:  T Palomo; R J Beninger; R M Kostrzewa; T Archer
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

3.  Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.

Authors:  Matthew B McQueen; B Devlin; Stephen V Faraone; Vishwajit L Nimgaonkar; Pamela Sklar; Jordan W Smoller; Rami Abou Jamra; Margot Albus; Silviu-Alin Bacanu; Miron Baron; Thomas B Barrett; Wade Berrettini; Deborah Blacker; William Byerley; Sven Cichon; Willam Coryell; Nick Craddock; Mark J Daly; J Raymond Depaulo; Howard J Edenberg; Tatiana Foroud; Michael Gill; T Conrad Gilliam; Marian Hamshere; Ian Jones; Lisa Jones; Suh-Hang Juo; John R Kelsoe; David Lambert; Christoph Lange; Bernard Lerer; Jianjun Liu; Wolfgang Maier; James D Mackinnon; Melvin G McInnis; Francis J McMahon; Dennis L Murphy; Markus M Nothen; John I Nurnberger; Carlos N Pato; Michele T Pato; James B Potash; Peter Propping; Ann E Pulver; John P Rice; Marcella Rietschel; William Scheftner; Johannes Schumacher; Ricardo Segurado; Kristel Van Steen; Weiting Xie; Peter P Zandi; Nan M Laird
Journal:  Am J Hum Genet       Date:  2005-08-15       Impact factor: 11.025

Review 4.  Genetic substrates of bipolar disorder risk in Latino families.

Authors:  Michael Escamilla; Camille Merhi
Journal:  Mol Psychiatry       Date:  2022-08-10       Impact factor: 13.437

5.  A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search.

Authors:  Andrea Angius; Enrico Petretto; Giovanni Battista Maestrale; Paola Forabosco; Giuseppina Casu; Daniela Piras; Manuela Fanciulli; Mario Falchi; Paola Maria Melis; Mario Palermo; Mario Pirastu
Journal:  Am J Hum Genet       Date:  2002-09-12       Impact factor: 11.025

6.  Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families.

Authors:  M Daniele Fallin; Virginia K Lasseter; Paula S Wolyniec; John A McGrath; Gerald Nestadt; David Valle; Kung-Yee Liang; Ann E Pulver
Journal:  Am J Hum Genet       Date:  2004-06-18       Impact factor: 11.025

Review 7.  Genetic variation and shared biological susceptibility underlying comorbidity in neuropsychiatry.

Authors:  Tomas Palomo; Richard M Kostrzewa; Richard J Beninger; Trevor Archer
Journal:  Neurotox Res       Date:  2007-07       Impact factor: 3.911
  7 in total

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