Literature DB >> 6572017

Protein engineering.

K M Ulmer.   

Abstract

The prospects for protein engineering, including the roles of x-ray crystallography, chemical synthesis of DNA, and computer modelling of protein structure and folding, are discussed. It is now possible to attempt to modify many different properties of proteins by combining information on crystal structure and protein chemistry with artificial gene synthesis. Such techniques offer the potential for altering protein structure and function in ways not possible by any other method.

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Year:  1983        PMID： 6572017     DOI： 10.1126/science.6572017

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  15 in total

Review 1.  Enzyme stabilization: state of the art.

Authors:  L Gianfreda; M R Scarfi
Journal:  Mol Cell Biochem       Date:  1991-02-02       Impact factor: 3.396

2.  Protein engineering: security implications. The increasing ability to manipulate protein toxins for hostile purposes has prompted calls for regulation.

Authors:  Jonathan B Tucker; Craig Hooper
Journal:  EMBO Rep       Date:  2006-07       Impact factor: 8.807

3.  Activity expressed from cloned Anacystis nidulans large and small subunit ribulose bisphosphate carboxylase genes.

Authors:  J T Christeller; B E Terzaghi; D F Hill; W A Laing
Journal:  Plant Mol Biol       Date:  1985-07       Impact factor: 4.076

4.  Genetic engineering. A new biotechnology.

Authors:  H O Halvorson
Journal:  Cell Biophys       Date:  1986-12

5.  Dependence of conformational stability on hydrophobicity of the amino acid residue in a series of variant proteins substituted at a unique position of tryptophan synthase alpha subunit.

Authors:  K Yutani; K Ogasahara; T Tsujita; Y Sugino
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

6.  Structure of proteins with single-site mutations: a minimum perturbation approach.

Authors:  H H Shih; J Brady; M Karplus
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

Review 7.  Regeneration of nicotinamide cofactors for use in organic synthesis.

Authors:  H K Chenault; G M Whitesides
Journal:  Appl Biochem Biotechnol       Date:  1987-03       Impact factor: 2.926

Review 8.  Enzyme engineering.

Authors:  W H Rastetter
Journal:  Appl Biochem Biotechnol       Date:  1983-10       Impact factor: 2.926

9.  Biosynthesis of a protein containing a nonprotein amino acid by Escherichia coli: L-2-aminohexanoic acid at position 21 in human epidermal growth factor.

Authors:  H Koide; S Yokoyama; G Kawai; J M Ha; T Oka; S Kawai; T Miyake; T Fuwa; T Miyazawa
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

10.  Improvement of a useful enzyme (subtilisin BPN') by an experimental evolution system.

Authors:  T Tange; S Taguchi; S Kojima; K Miura; H Momose
Journal:  Appl Microbiol Biotechnol       Date:  1994-04       Impact factor: 4.813
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