Literature DB >> 16819442

Protein engineering: security implications. The increasing ability to manipulate protein toxins for hostile purposes has prompted calls for regulation.

Jonathan B Tucker1, Craig Hooper.   

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Year:  2006        PMID： 16819442      PMCID： PMC1490303          DOI： 10.1038/sj.embor.7400677

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


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  15 in total

1.  Fusion protein toxins based on diphtheria toxin: selective targeting of growth factor receptors of eukaryotic cells.

Authors:  J C vanderSpek; J R Murphy
Journal:  Methods Enzymol       Date:  2000       Impact factor: 1.600

Review 2.  Chimeric fusion proteins--Pseudomonas exotoxin-based.

Authors:  R J Kreitman
Journal:  Curr Opin Investig Drugs       Date:  2001-09

Review 3.  Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agents.

Authors:  J M Madsen
Journal:  Clin Lab Med       Date:  2001-09       Impact factor: 1.935

4.  The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components.

Authors:  Holger Barth; Robert Roebling; Michaela Fritz; Klaus Aktories
Journal:  J Biol Chem       Date:  2001-12-06       Impact factor: 5.157

5.  Protein engineering.

Authors:  K M Ulmer
Journal:  Science       Date:  1983-02-11       Impact factor: 47.728

6.  Scorpion toxins as natural scaffolds for protein engineering.

Authors:  C Vita; C Roumestand; F Toma; A Ménez
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205

7.  Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells.

Authors:  T Kiyokawa; D P Williams; C E Snider; T B Strom; J R Murphy
Journal:  Protein Eng       Date:  1991-04

Review 8.  Superantigens and their potential role in human disease.

Authors:  B L Kotzin; D Y Leung; J Kappler; P Marrack
Journal:  Adv Immunol       Date:  1993       Impact factor: 3.543

9.  Cytotoxic effects of a chimeric protein consisting of tetanus toxin light chain and anthrax toxin lethal factor in non-neuronal cells.

Authors:  N Arora; L C Williamson; S H Leppla; J L Halpern
Journal:  J Biol Chem       Date:  1994-10-21       Impact factor: 5.157

10.  Direct expression in E. coli of a functionally active protein A--snake toxin fusion protein.

Authors:  F Ducancel; J C Boulain; O Trémeau; A Ménez
Journal:  Protein Eng       Date:  1989-11
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  2 in total

1.  The bioterrorism threat and dual-use biotechnological research: an Israeli perspective.

Authors:  David Friedman; Bracha Rager-Zisman; Eitan Bibi; Alex Keynan
Journal:  Sci Eng Ethics       Date:  2008-06-19       Impact factor: 3.777

2.  T rays vs. terrorists: widening the security spectrum.

Authors:  Valerie J Brown
Journal:  Environ Health Perspect       Date:  2006-09       Impact factor: 9.031
  2 in total

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