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Literature DB >> 6548562

Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis.

T A Millican, G A Mock, M A Chauncey, T P Patel, M A Eaton, J Gunning, S D Cutbush, S Neidle, J Mann.

Abstract

The syntheses of 1,2-dideoxy-D-ribofuranose and 1,2-dideoxy-1-phenyl-beta-D-ribofuranose are described. Oligodeoxynucleotides containing these analogues have been synthesised and hybridized to their complementary strands. Hypochromicity studies have shown that these duplices are less stable than either the totally complementary duplex or those containing A.C and G.T mismatches.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1984 PMID： 6548562 PMCID： PMC320173 DOI： 10.1093/nar/12.19.7435

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

12 in total

1. Stereochemistry of nucleic acids and their constituents. X. Solid-state base-stacking patterns in nucleic acid constituents and polynucleotides.

Authors: C E Bugg; J M Thomas; M Sundaralingam; S T Rao
Journal: Biopolymers Date: 1971 Impact factor: 2.505

2. Purine nucleosides. XI. The synthesis of 2'-deoxy-9-alpha- and-beta-D-ribofuranosylpurines and the correlation of their anomeric structure with proton magnetic resonance spectra.

Authors: M J Robins; R K Robins
Journal: J Am Chem Soc Date: 1965-11-05 Impact factor: 15.419

3. Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin.

Authors: T J Harris; P A Lowe; A Lyons; P G Thomas; M A Eaton; T A Millican; T P Patel; C C Bose; N H Carey; M T Doel
Journal: Nucleic Acids Res Date: 1982-04-10 Impact factor: 16.971

4. Structure, dynamics, and energetics of deoxyguanosine . thymidine wobble base pair formation in the self-complementary d(CGTGAATTCGCG) duplex in solution.

Authors: D J Patel; S A Kozlowski; L A Marky; J A Rice; C Broka; J Dallas; K Itakura; K J Breslauer
Journal: Biochemistry Date: 1982-02-02 Impact factor: 3.162

5. Improvements to solid phase phosphotriester synthesis of deoxyoligonucleotides.

Authors: T P Patel; T A Millican; C C Bose; R C Titmas; G A Mock; M A Eaton
Journal: Nucleic Acids Res Date: 1982-09-25 Impact factor: 16.971

6. DNA sequence analysis: a general, simple and rapid method for sequencing large oligodeoxyribonucleotide fragments by mapping.

Authors: E Jay; R Bambara; R Padmanabhan; R Wu
Journal: Nucleic Acids Res Date: 1974-03 Impact factor: 16.971

7. Color coded triarylmethyl protecting groups useful for deoxypolynucleotide synthesis.

Authors: E F Fisher; M H Caruthers
Journal: Nucleic Acids Res Date: 1983-03-11 Impact factor: 16.971

8. Solid phase synthesis of polynucleotides. VIII. Synthesis of mixed oligodeoxyribonucleotides by the phosphotriester solid phase method.

Authors: Y Ike; S Ikuta; M Sato; T Huang; K Itakura
Journal: Nucleic Acids Res Date: 1983-01-25 Impact factor: 16.971

9. Solid phase synthesis of polynucleotides. VI. Further studies on polystyrene copolymers for the solid support.

Authors: H Ito; Y Ike; S Ikuta; K Itakura
Journal: Nucleic Acids Res Date: 1982-03-11 Impact factor: 16.971

10. C-nucleoside studies. I. Synthesis of (2,3,5-tri-O-benzyl-alpha(and beta)-D-ribofuranosyl)ethyne.

Authors: J G Buchanan; A R Edgar; M J Power
Journal: J Chem Soc Perkin 1 Date: 1974

40 in total

1. Abasic sites in duplex DNA: molecular modeling of sequence-dependent effects on conformation.

Authors: L Ayadi; C Coulombeau; R Lavery
Journal: Biophys J Date: 1999-12 Impact factor: 4.033

2. NMR structure of a DNA duplex containing nucleoside analog 1-(2'-deoxy-beta-D-ribofuranosyl)-3-nitropyrrole and the structure of the unmodified control.

Authors: D A Klewer; A Hoskins; P Zhang; V J Davisson; D E Bergstrom; A C LiWang
Journal: Nucleic Acids Res Date: 2000-11-15 Impact factor: 16.971

Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis.

1. Stereochemistry of nucleic acids and their constituents. X. Solid-state base-stacking patterns in nucleic acid constituents and polynucleotides.

2. Purine nucleosides. XI. The synthesis of 2'-deoxy-9-alpha- and-beta-D-ribofuranosylpurines and the correlation of their anomeric structure with proton magnetic resonance spectra.

3. Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin.

4. Structure, dynamics, and energetics of deoxyguanosine . thymidine wobble base pair formation in the self-complementary d(CGTGAATTCGCG) duplex in solution.

5. Improvements to solid phase phosphotriester synthesis of deoxyoligonucleotides.

6. DNA sequence analysis: a general, simple and rapid method for sequencing large oligodeoxyribonucleotide fragments by mapping.

7. Color coded triarylmethyl protecting groups useful for deoxypolynucleotide synthesis.

8. Solid phase synthesis of polynucleotides. VIII. Synthesis of mixed oligodeoxyribonucleotides by the phosphotriester solid phase method.

9. Solid phase synthesis of polynucleotides. VI. Further studies on polystyrene copolymers for the solid support.

10. C-nucleoside studies. I. Synthesis of (2,3,5-tri-O-benzyl-alpha(and beta)-D-ribofuranosyl)ethyne.

1. Abasic sites in duplex DNA: molecular modeling of sequence-dependent effects on conformation.

2. NMR structure of a DNA duplex containing nucleoside analog 1-(2'-deoxy-beta-D-ribofuranosyl)-3-nitropyrrole and the structure of the unmodified control.

3. New insights into the structure of abasic DNA from molecular dynamics simulations.

4. Universal bases for hybridization, replication and chain termination.

Review 5. Survey and summary: The applications of universal DNA base analogues.

6. Selective and Stable DNA Base Pairing without Hydrogen Bonds.

7. Experimental Measurement of Aromatic Stacking Affinities in the Context of Duplex DNA.

8. C-Nucleosides Derived from Simple Aromatic Hydrocarbons.

9. Synthesis and properties of oligonucleotides containing 2'-deoxynebularine and 2'-deoxyxanthosine.

10. Synthesis and hybridization of dodecadeoxyribonucleotides containing a fluorescent pyridopyrimidine deoxynucleoside.