Literature DB >> 6525169

Involvement of hysteretic effects in the inhibition of carnitine palmitoyltransferase by malonyl-CoA.

G A Cook.   

Abstract

Carnitine palmitoyltransferase in its normal mitochondrial environment behaves as a hysteretic enzyme, exhibiting slow changes in reaction rate after the addition of oleoyl-CoA or malonyl-CoA. Reaction rates become constant after a short time, but the sensitivity of the enzyme from fed rats to the inhibition by malonyl-CoA remains much greater than that of starved rats.

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Year:  1984        PMID： 6525169      PMCID： PMC1144541          DOI： 10.1042/bj2241015

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

Review 1.  Slow transitions and hysteretic behavior in enzymes.

Authors:  C Frieden
Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

2.  Kinetic aspects of regulation of metabolic processes. The hysteretic enzyme concept.

Authors:  C Frieden
Journal:  J Biol Chem       Date:  1970-11-10       Impact factor: 5.157

3.  Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro.

Authors:  V A Zammit
Journal:  Biochem J       Date:  1983-03-15       Impact factor: 3.857

4.  Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values.

Authors:  G A Cook
Journal:  J Biol Chem       Date:  1984-10-10       Impact factor: 5.157

5.  Effects of fasting, adrenalectomy and streptozotocin-diabetes on sensitivity of hepatic carnitine acyltransferase to malonyl CoA.

Authors:  E D Saggerson; C A Carpenter
Journal:  FEBS Lett       Date:  1981-07-06       Impact factor: 4.124

6.  Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats.

Authors:  G A Cook; D A Otto; N W Cornell
Journal:  Biochem J       Date:  1980-12-15       Impact factor: 3.857

7.  Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Evidence for an unidentified regulatory component of the system.

Authors:  J A Ontko; M L Johns
Journal:  Biochem J       Date:  1980-12-15       Impact factor: 3.857

8.  Time-dependence of inhibition of carnitine palmitoyltransferase I by malonyl-CoA in mitochondria isolated from livers of fed or starved rats. Evidence for transition of the enzyme between states of low and high affinity for malonyl-CoA.

Authors:  V A Zammit
Journal:  Biochem J       Date:  1984-03-01       Impact factor: 3.857

9.  Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I.

Authors:  T W Stephens; G A Cook; R A Harris
Journal:  Biochem J       Date:  1983-05-15       Impact factor: 3.857

10.  Reversible sensitization and desensitization of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in isolated rat liver mitochondria. Significance for the mechanism of malonyl-CoA-induced sensitization.

Authors:  V A Zammit
Journal:  Biochem J       Date:  1983-09-15       Impact factor: 3.857
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  7 in total

1.  Effect of starvation and diabetes on the sensitivity of carnitine palmitoyltransferase I to inhibition by 4-hydroxyphenylglyoxylate.

Authors:  T W Stephens; R A Harris
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

2.  Lipid molecular order in liver mitochondrial outer membranes, and sensitivity of carnitine palmitoyltransferase I to malonyl-CoA.

Authors:  V A Zammit; C G Corstorphine; M P Kolodziej; F Fraser
Journal:  Lipids       Date:  1998-04       Impact factor: 1.880

3.  Intertissue differences in the hysteretic behaviour of carnitine palmitoyltransferase in the presence of malonyl-CoA.

Authors:  A C Lloyd; C A Carpenter; E D Saggerson
Journal:  Biochem J       Date:  1986-07-01       Impact factor: 3.857

4.  Hysteretic behaviour of carnitine palmitoyltransferase. The effect of preincubation with malonyl-CoA.

Authors:  G A Cook; K A Cox
Journal:  Biochem J       Date:  1986-06-15       Impact factor: 3.857

5.  Effects of the mode of addition of acyl-CoA on the initial rate of formation of acylcarnitine in the presence of carnitine by intact rat liver mitochondria in vitro.

Authors:  V A Zammit
Journal:  Biochem J       Date:  1985-07-01       Impact factor: 3.857

6.  Octadecatrienoic acids as the substrates for the key enzymes in glycerolipid biosynthesis and fatty acid oxidation in rat liver.

Authors:  T Ide; M Murata; M Sugano
Journal:  Lipids       Date:  1995-08       Impact factor: 1.880

7.  Studies on the activation in vitro of carnitine palmitoyltransferase I in liver mitochondria from normal, diabetic and glucagon-treated rats.

Authors:  B D Grantham; V A Zammit
Journal:  Biochem J       Date:  1987-04-01       Impact factor: 3.857
  7 in total

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