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Literature DB >> 3800884

Intertissue differences in the hysteretic behaviour of carnitine palmitoyltransferase in the presence of malonyl-CoA.

A C Lloyd, C A Carpenter, E D Saggerson.

Abstract

In the presence of malonyl-CoA, the overt form of carnitine palmitoyltransferase (CPT1) in mitochondria from rat liver, kidney cortex, heart, skeletal muscle and brown adipose tissue shows non-linear time courses, suggesting hysteretic behaviour. The pattern of this hysteresis is similar in heart, skeletal muscle and brown adipose tissue, but the hysteretic behaviour of the enzyme in these three tissues differs markedly from that seen in liver and kidney.

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Year: 1986 PMID： 3800884 PMCID： PMC1146980 DOI： 10.1042/bj2370289

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

17 in total

1. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

Review 2. Slow transitions and hysteretic behavior in enzymes.

Authors: C Frieden
Journal: Annu Rev Biochem Date: 1979 Impact factor: 23.643

3. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro.

Authors: V A Zammit
Journal: Biochem J Date: 1983-03-15 Impact factor: 3.857

4. Sensitivity of brown-adipose-tissue carnitine palmitoyltransferase to inhibition by malonyl-CoA.

Authors: E D Saggerson; C A Carpenter
Journal: Biochem J Date: 1982-04-15 Impact factor: 3.857

5. Carnitine acyltransferase activities in rat liver and heart measured with palmitoyl-CoA and octanoyl-CoA. Latency, effects of K+, bivalent metal ions and malonyl-CoA.

Authors: E D Saggerson
Journal: Biochem J Date: 1982-02-15 Impact factor: 3.857

6. Interaction of malonyl-CoA and related compounds with mitochondria from different rat tissues. Relationship between ligand binding and inhibition of carnitine palmitoyltransferase I.

Authors: S E Mills; D W Foster; J D McGarry
Journal: Biochem J Date: 1983-07-15 Impact factor: 3.857

7. Time-dependence of inhibition of carnitine palmitoyltransferase I by malonyl-CoA in mitochondria isolated from livers of fed or starved rats. Evidence for transition of the enzyme between states of low and high affinity for malonyl-CoA.

Authors: V A Zammit
Journal: Biochem J Date: 1984-03-01 Impact factor: 3.857

8. Effects of thyroidectomy and starvation on the activity and properties of hepatic carnitine palmitoyltransferase.

Authors: E D Saggerson; C A Carpenter; B S Tselentis
Journal: Biochem J Date: 1982-12-15 Impact factor: 3.857

9. Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I.

Authors: T W Stephens; G A Cook; R A Harris
Journal: Biochem J Date: 1983-05-15 Impact factor: 3.857

10. Effects of pH on the interaction of substrates and malonyl-CoA with mitochondrial carnitine palmitoyltransferase I.

Authors: S E Mills; D W Foster; J D McGarry
Journal: Biochem J Date: 1984-04-15 Impact factor: 3.857

8 in total

Review 1. The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.

Authors: V A Zammit
Journal: Biochem J Date: 1999-11-01 Impact factor: 3.857

2. Sensitivity of inhibition of rat liver mitochondrial outer-membrane carnitine palmitoyltransferase by malonyl-CoA to chemical- and temperature-induced changes in membrane fluidity.

Authors: M P Kolodziej; V A Zammit
Journal: Biochem J Date: 1990-12-01 Impact factor: 3.857

7. Studies on the activation in vitro of carnitine palmitoyltransferase I in liver mitochondria from normal, diabetic and glucagon-treated rats.

Authors: B D Grantham; V A Zammit
Journal: Biochem J Date: 1987-04-01 Impact factor: 3.857

8. Hexanoic, Octanoic and Decanoic Acids Promote Basal and Insulin-Induced Phosphorylation of the Akt-mTOR Axis and a Balanced Lipid Metabolism in the HepG2 Hepatoma Cell Line.

Authors: Sabri Ahmed Rial; Gaetan Ravaut; Tommy B Malaret; Karl-F Bergeron; Catherine Mounier
Journal: Molecules Date: 2018-09-11 Impact factor: 4.411