Literature DB >> 6882380

Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I.

T W Stephens, G A Cook, R A Harris.   

Abstract

Malonyl-CoA inhibition of carnitine palmitoyltransferase I was found to be very pH-dependent. Malonyl-CoA concentrations causing 50% inhibition (I50) at pH 6.0, 6.5, 7.0, 7.5 and 8.0 were 0.04, 1, 9, 40 and 200 microM respectively. It is suggested that a lowering of intracellular pH, such as might occur in ketoacidosis, may attenuate hepatic fatty acid oxidation by increasing malonyl-CoA sensitivity of carnitine palmitoyltransferase I.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6882380      PMCID： PMC1152076          DOI： 10.1042/bj2120521

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  Comparison of the carnitine acyltransferase activites from rat liver peroxisomes and microsomes.

Authors:  M A Markwell; N E Tolbert; L L Bieber
Journal:  Arch Biochem Biophys       Date:  1976-10       Impact factor: 4.013

2.  The effect of fasting on esterification of palmitate by rat liver in vitro.

Authors:  B Rubenstein; D Rubinstein
Journal:  Can J Biochem       Date:  1966-01

Review 3.  Phosphofructokinase.

Authors:  T E Mansour
Journal:  Curr Top Cell Regul       Date:  1972

4.  The concentration of malonyl-coenzyme A and the control of fatty acid synthesis in vivo.

Authors:  R W Guynn; D Veloso; R L Veech
Journal:  J Biol Chem       Date:  1972-11-25       Impact factor: 5.157

5.  Metabolism of free fatty acids in isolated liver cells. Factors affecting the partition between esterification and oxidation.

Authors:  J A Ontko
Journal:  J Biol Chem       Date:  1972-03-25       Impact factor: 5.157

Review 6.  Regulation of hepatic fatty acid oxidation and ketone body production.

Authors:  J D McGarry; D W Foster
Journal:  Annu Rev Biochem       Date:  1980       Impact factor: 23.643

7.  Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA.

Authors:  J D McGarry; G F Leatherman; D W Foster
Journal:  J Biol Chem       Date:  1978-06-25       Impact factor: 5.157

8.  Cellular energy metabolism, trans-plasma and trans-mitochondrial membrane potentials, and pH gradients in mouse neuroblastoma.

Authors:  C Deutsch; M Erecińska; R Werrlein; I A Silver
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

9.  Determination of the mitochondrial protonmotive force in isolated hepatocytes.

Authors:  J B Hoek; D G Nicholls; J R Williamson
Journal:  J Biol Chem       Date:  1980-02-25       Impact factor: 5.157

10.  Ketogenesis and malonyl coenzyme A content of isolated rat hepatocytes.

Authors:  G A Cook; M T King; R L Veech
Journal:  J Biol Chem       Date:  1978-04-25       Impact factor: 5.157
View more
  19 in total

1.  Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.

Authors:  M Morillas; J Clotet; B Rubí; D Serra; J Ariño; F G Hegardt; G Asins
Journal:  Biochem J       Date:  2000-10-15       Impact factor: 3.857

2.  Effect of starvation and diabetes on the sensitivity of carnitine palmitoyltransferase I to inhibition by 4-hydroxyphenylglyoxylate.

Authors:  T W Stephens; R A Harris
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

Review 3.  Role of insulin in hepatic fatty acid partitioning: emerging concepts.

Authors:  V A Zammit
Journal:  Biochem J       Date:  1996-02-15       Impact factor: 3.857

4.  Regulation by oestrogen of carnitine palmitoyltransferase in hepatic mitochondria.

Authors:  I Weinstein; G A Cook; M Heimberg
Journal:  Biochem J       Date:  1986-07-15       Impact factor: 3.857

5.  Intertissue differences in the hysteretic behaviour of carnitine palmitoyltransferase in the presence of malonyl-CoA.

Authors:  A C Lloyd; C A Carpenter; E D Saggerson
Journal:  Biochem J       Date:  1986-07-01       Impact factor: 3.857

6.  Octadecatrienoic acids as the substrates for the key enzymes in glycerolipid biosynthesis and fatty acid oxidation in rat liver.

Authors:  T Ide; M Murata; M Sugano
Journal:  Lipids       Date:  1995-08       Impact factor: 1.880

7.  Effects of incubation at physiological temperatures on the concentration-dependence of [2-14C]malonyl-CoA binding to rat liver mitochondria.

Authors:  V A Zammit; C G Corstorphine
Journal:  Biochem J       Date:  1985-10-15       Impact factor: 3.857

8.  Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues.

Authors:  S T Swanson; D W Foster; J D McGarry; N F Brown
Journal:  Biochem J       Date:  1998-11-01       Impact factor: 3.857

9.  Involvement of microsomal vesicles in part of the sensitivity of carnitine palmitoyltransferase I to malonyl-CoA inhibition in mitochondrial fractions of rat liver.

Authors:  I Niot; F Pacot; P Bouchard; J Gresti; A Bernard; J Bezard; P Clouet
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

10.  Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase.

Authors:  N N A'Bháird; R R Ramsay
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.