Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.

Literature DB >> 6452060

FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.

Abstract

Experiments designed to illuminate the mechanism by which folic acid and thymidine inhibit expression of the Xq28 fragile site in human lymphocytes are described. The fragile site is induced by 5-fluorodeoxyuridine (FUdR), a potent inhibitor of thymidylate synthetase, in the presence of otherwise inhibiting concentrations of folic acid but not in the presence of thymidine. These results indicate that the fragile site is expressed because of depletion of deoxythymidine monophosphate (dTMP) available for DNA synthesis.

Entities: Chemical Species

Mesh：

Substances：

Year: 1981 PMID： 6452060 PMCID： PMC1684940

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

13 in total

1. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

Authors: G R Sutherland
Journal: Am J Hum Genet Date: 1979-03 Impact factor: 11.025

2. Characterization of a mutator gene in Chinese hamster ovary cells.

Authors: M Meuth; N L'Heureux-Huard; M Trudel
Journal: Proc Natl Acad Sci U S A Date: 1979-12 Impact factor: 11.205

3. Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics.

Authors: G R Sutherland
Journal: Am J Hum Genet Date: 1979-03 Impact factor: 11.025

Review 4. Thymidylate synthetase.

Authors: M Friedkin
Journal: Adv Enzymol Relat Areas Mol Biol Date: 1973

Review 5. Genetic aspects of folate metabolism.

Authors: R W Erbe
Journal: Adv Hum Genet Date: 1979

6. A marker X chromosome.

Authors: H A Lubs
Journal: Am J Hum Genet Date: 1969-05 Impact factor: 11.025

7. Marker X chromosomes, mental retardation and macro-orchidism.

Authors: G Turner; R Till; A Daniel
Journal: N Engl J Med Date: 1978-12-28 Impact factor: 91.245

8. X-linked mental retardation with macro-orchidism and marker X chromosomes.

Authors: P N Howard-Peebles; G R Stoddard
Journal: Hum Genet Date: 1979-09 Impact factor: 4.132

9. Familial X-linked mental retardation with an X chromosome abnormality.

Authors: J Harvey; C Judge; S Wiener
Journal: J Med Genet Date: 1977-02 Impact factor: 6.318

10. Expression in fibroblast culture of the satellited-X chromosome associated with familial sex-linked mental retardation.

Authors: P B Jacky; F J Dill
Journal: Hum Genet Date: 1980-02 Impact factor: 4.132

60 in total

1. A single lymphocyte culture for fragile X induction and prometaphase chromosome analysis.

Authors: M J Griffiths; M C Strachan
Journal: J Med Genet Date: 1991-12 Impact factor: 6.318

Review 2. Medical genetics.

Authors: M Super
Journal: Postgrad Med J Date: 1991-07 Impact factor: 2.401

3. "Spontaneous" FRA16B is a hot spot for sister chromatid exchanges.

Authors: T Lukusa; E Meulepas; J P Fryns; H Van den Berghe; J J Cassiman
Journal: Hum Genet Date: 1991-09 Impact factor: 4.132

4. Improved fragile site detection with trimethoprim.

Authors: D A McLean; M J Faed
Journal: Hum Genet Date: 1990-07 Impact factor: 4.132

5. Linkage studies of X-linked mental retardation: high frequency of recombination in the telomeric region of the human X chromosome (fragile site/linkage/recombination/X chromosome).

Authors: K E Davies; M G Mattei; J F Mattei; H Veenema; S McGlade; K Harper; N Tommerup; K B Nielsen; M Mikkelsen; P Beighton
Journal: Hum Genet Date: 1985 Impact factor: 4.132

6. Induction of the fragile X on BrdU-substituted chromosomes with direct visualization of sister chromatid exchanges on banded chromosomes.

Authors: N Tommerup
Journal: Hum Genet Date: 1989-03 Impact factor: 4.132

10. Cytogenetic investigations in mentally retarded and normal males from 14 families with the fragile site at Xq28. Results of folic acid treatment on fra(X) expression.

Authors: K B Nielsen; N Tommerup
Journal: Hum Genet Date: 1984 Impact factor: 4.132