Literature DB >> 2370056

Improved fragile site detection with trimethoprim.

D A McLean1, M J Faed.   

Abstract

The effect of trimethoprim, an inhibitor of dihydrofolate reductase, in demonstrating the presence of fragile sites on human chromosomes was investigated. Lymphocyte cultures with 20 mg/l trimethoprim added at the onset of incubation gave consistently higher frequencies of fragile sites than the other culture regimes tested.

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Year:  1990        PMID： 2370056     DOI： 10.1007/bf00193204

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

1.  Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium.

Authors:  G R Sutherland
Journal:  Science       Date:  1977-07-15       Impact factor: 47.728

2.  Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1979-03       Impact factor: 11.025

3.  Inhibitor binding analysis of dihydrofolate reductases from various species.

Authors:  J J Burchall; G H Hitchings
Journal:  Mol Pharmacol       Date:  1965-09       Impact factor: 4.436

4.  The fragile X(q27) form of X-linked mental retardation: FUdR as an inducing agent for fra(X)(q27) expression in lymphocytes, fibroblasts, and amniocytes.

Authors:  R Brookwell; A Daniel; G Turner; J Fishburn
Journal:  Am J Med Genet       Date:  1982-10

5.  A simple method to demonstrate the fragile X chromosome in fibroblasts.

Authors:  C Fonatsch
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

6.  Expression in lymphocyte and fibroblast culture of the fragile X chromosome: a new technical approach.

Authors:  M G Mattei; J F Mattei; I Vidal; F Giraud
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

7.  Excess thymidine induces folate sensitive fragile sites.

Authors:  G R Sutherland; E Baker; A Fratini
Journal:  Am J Med Genet       Date:  1985-10

8.  [X chromosome fragility and effects of trimethoprim].

Authors:  J Lejeune; N Legrand; J Lafourcade; M O Rethoré; O Raoul; C Maunoury
Journal:  Ann Genet       Date:  1982

9.  [Fragility of the X chromosome and inhibition of dihydrofolate reductase. Comparison of the effects of 2 antibiotics: trimethoprim and pyrimethamine].

Authors:  M P Calva-Mercado; C Maunoury; M O Rethoré; J Lejeune
Journal:  Ann Genet       Date:  1983

10.  FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.

Authors:  T W Glover
Journal:  Am J Hum Genet       Date:  1981-03       Impact factor: 11.025
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  2 in total

1.  Relative sensitivity of fish and mammalian cells to the antibiotic, trimethoprim: cytotoxic and genotoxic responses as determined by neutral red retention, Comet and micronucleus assays.

Authors:  Elena Papis; Simon J Davies; Awadhesh N Jha
Journal:  Ecotoxicology       Date:  2010-11-21       Impact factor: 2.823

2.  Molecular and cytogenetic analyses of autism in Taiwan.

Authors:  S Y Li; Y C Chen; T J Lai; C Y Hsu; Y C Wang
Journal:  Hum Genet       Date:  1993-11       Impact factor: 4.132
  2 in total

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