Literature DB >> 3315877

Demonstration of pepsinogen C in human pancreatic islets.

P B Szecsi1, H Halgreen, S S Poulsen, C K Axelsson, M Damkjaer-Nielsen, T Kjaer, B Foltmann.   

Abstract

Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.

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Year:  1987        PMID： 3315877      PMCID： PMC1433480          DOI： 10.1136/gut.28.10.1208

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  13 in total

1.  Pepsinogen in human seminal fluid.

Authors:  F LUNDQUIST; H H SEEDORFF
Journal:  Nature       Date:  1952-12-27       Impact factor: 49.962

2.  Acidic protease from human seminal plasma. Purification and some properties of active enzyme and of proenzyme.

Authors:  P Ruenwongsa; M Chulavatnatol
Journal:  J Biol Chem       Date:  1975-10-10       Impact factor: 5.157

3.  Radioimmunoassay of group I pepsinogens in serum.

Authors:  I M Samloff; W M Liebman
Journal:  Gastroenterology       Date:  1974-04       Impact factor: 22.682

4.  Cellular localization of the group II pepsinogens in human stomach and duodenum by immunofluorescence.

Authors:  I M Samloff; W M Liebman
Journal:  Gastroenterology       Date:  1973-07       Impact factor: 22.682

5.  Detection of proteases by clotting of casein after gel electrophoresis.

Authors:  B Foltmann; P B Szecsi; N I Tarasova
Journal:  Anal Biochem       Date:  1985-05-01       Impact factor: 3.365

6.  Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.

Authors:  W A Reid; L Vongsorasak; J Svasti; M J Valler; J Kay
Journal:  Cell Tissue Res       Date:  1984       Impact factor: 5.249

7.  Human prostatic gastricsinogen: the precursor of seminal fluid acid proteinase.

Authors:  L Chiang; L Contreras; J Chiang; P H Ward
Journal:  Arch Biochem Biophys       Date:  1981-08       Impact factor: 4.013

8.  Solid-phase double-antibody radioimmunoassay of pepsinogen I in serum.

Authors:  C K Axelsson; M Damkjaer Nielsen; A M Kappelgaard
Journal:  Clin Chim Acta       Date:  1982-06-03       Impact factor: 3.786

9.  Purification and immunochemical characterization of group II pepsinogens in human seminal fluid.

Authors:  I M Samloff; W M Liebman
Journal:  Clin Exp Immunol       Date:  1972-07       Impact factor: 4.330

10.  Heterogeneity of chloramine T- and lactoperoxidase-radioiodinated human calcitonin.

Authors:  W C Dermody; A G Levy; P E Davis; J K Plowman
Journal:  Clin Chem       Date:  1979-06       Impact factor: 8.327
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