Literature DB >> 6418375

Characterization of human transforming genes from chemically transformed, teratocarcinoma, and pancreatic carcinoma cell lines.

C S Cooper, D G Blair, M K Oskarsson, M A Tainsky, L A Eader, G F Vande Woude.   

Abstract

Dominant transforming genes that were transferred to mouse NIH3T3 cells by cellular DNAs prepared from a chemically transformed human cell line (MNNG-HOS), a human teratocarcinoma cell line (PA1), and a human pancreatic carcinoma cell line (A1165) were characterized (a) analyzing the repetitive human DNA sequences that were associated with the transforming gene and (b) determining their relationship to the oncogenes of the Harvey (rasH) and Kirsten (rasK) sarcoma viruses and to the human neuroblastoma transforming gene (rasN). The results show that the transforming gene activated in the teratocarcinoma cell line is identical to the neuroblastoma transforming gene and that the transforming gene of the pancreatic carcinoma cell line is a human homologue of rasK. In contrast, the transforming gene activated in the chemically transformed human cell line showed no detectable homology to rasK, rasH, and rasN.

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Year:  1984        PMID： 6418375

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  25 in total

1.  Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor.

Authors:  Ermanno Gherardi; Mark E Youles; Ricardo N Miguel; Tom L Blundell; Luisa Iamele; Julian Gough; Abhishek Bandyopadhyay; Guido Hartmann; P Jonathan G Butler
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-03       Impact factor: 11.205

2.  The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions.

Authors:  N R Soman; P Correa; B A Ruiz; G N Wogan
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

Review 3.  Genetic markers on chromosome 7.

Authors:  L C Tsui
Journal:  J Med Genet       Date:  1988-05       Impact factor: 6.318

4.  Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.

Authors:  M Gonzatti-Haces; A Seth; M Park; T Copeland; S Oroszlan; G F Vande Woude
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

5.  Chromosome mediated gene transfer of six DNA markers linked to the cystic fibrosis locus on human chromosome seven.

Authors:  P J Scambler; H Y Law; R Williamson; C S Cooper
Journal:  Nucleic Acids Res       Date:  1986-09-25       Impact factor: 16.971

Review 6.  Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and invasion/metastasis.

Authors:  M Jeffers; S Rong; G F Vande Woude
Journal:  J Mol Med (Berl)       Date:  1996-09       Impact factor: 4.599

7.  Prenatal expression of MET receptor tyrosine kinase in the fetal mouse dorsal raphe nuclei and the visceral motor/sensory brainstem.

Authors:  Hsiao-Huei Wu; Pat Levitt
Journal:  Dev Neurosci       Date:  2013-03-20       Impact factor: 2.984

8.  Visualization of c-Ki-ras-2 oncogene sequences in human pancreas, a chemically induced transplantable carcinoma, and carcinomas of pancreas by in situ hybridization.

Authors:  I Parsa; C M Cleary; W H Marsh; K M Butt; C A Foye
Journal:  Int J Pancreatol       Date:  1986-12

9.  Human recipient cell for oncogene transfection studies.

Authors:  M A Tainsky; F L Shamanski; D Blair; G Vande Woude
Journal:  Mol Cell Biol       Date:  1987-03       Impact factor: 4.272

10.  Different effects of the polysaccharide levan on the oncogenicity of cells of two variants of Lewis lung carcinoma.

Authors:  Y Stark; J Leibovici
Journal:  Br J Exp Pathol       Date:  1986-02
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