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Literature DB >> 8892055

Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and invasion/metastasis.

Abstract

Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular process, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1996 PMID： 8892055 DOI： 10.1007/bf00204976

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

102 in total

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Authors: V Ellis; C Pyke; J Eriksen; H Solberg; K Danø
Journal: Ann N Y Acad Sci Date: 1992-12-04 Impact factor: 5.691

2. A protein tyrosine phosphatase activity associated with the hepatocyte growth factor/scatter factor receptor.

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Journal: J Biol Chem Date: 1993-08-25 Impact factor: 5.157

3. Autocrine hepatocyte growth factor/scatter factor-Met signaling induces transformation and the invasive/metastastic phenotype in C127 cells.

Authors: M Jeffers; S Rong; M Anver; G F Vande Woude
Journal: Oncogene Date: 1996-08-15 Impact factor: 9.867

4. Met expression and sarcoma tumorigenicity.

Authors: S Rong; M Jeffers; J H Resau; I Tsarfaty; M Oskarsson; G F Vande Woude
Journal: Cancer Res Date: 1993-11-15 Impact factor: 12.701

5. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor.

Authors: Y Uehara; O Minowa; C Mori; K Shiota; J Kuno; T Noda; N Kitamura
Journal: Nature Date: 1995-02-23 Impact factor: 49.962

6. Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients.

Authors: S Rong; L A Donehower; M F Hansen; L Strong; M Tainsky; M Jeffers; J H Resau; E Hudson; I Tsarfaty; G F Vande Woude
Journal: Cancer Res Date: 1995-05-01 Impact factor: 12.701

Review 7. Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

Authors: K Matsumoto; T Nakamura
Journal: Crit Rev Oncog Date: 1992

8. A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture.

Authors: T Shimomura; M Ochiai; J Kondo; Y Morimoto
Journal: Cytotechnology Date: 1992 Impact factor: 2.058

9. Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas.

Authors: C Liu; M Park; M S Tsao
Journal: Oncogene Date: 1992-01 Impact factor: 9.867

10. Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.

Authors: K Matsumoto; K Matsumoto; T Nakamura; R H Kramer
Journal: J Biol Chem Date: 1994-12-16 Impact factor: 5.157

72 in total

1. Activation of hepatocyte growth factor-met autocrine loop enhances tumorigenicity in a human lung adenocarcinoma cell line.

Authors: S Yi; M S Tsao
Journal: Neoplasia Date: 2000 May-Jun Impact factor: 5.715

2. HGF rescues colorectal cancer cells from EGFR inhibition via MET activation.

Authors: David Liska; Chin-Tung Chen; Thomas Bachleitner-Hofmann; James G Christensen; Martin R Weiser
Journal: Clin Cancer Res Date: 2010-11-22 Impact factor: 12.531

3. Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.

Authors: Lisa S Lock; Christiane R Maroun; Monica A Naujokas; Morag Park
Journal: Mol Biol Cell Date: 2002-06 Impact factor: 4.138

Review 4. Role of MetMAb (OA-5D5) in c-MET active lung malignancies.

Authors: Mosmi Surati; Premal Patel; Amy Peterson; Ravi Salgia
Journal: Expert Opin Biol Ther Date: 2011-12 Impact factor: 4.388

5. Activating mutations for the met tyrosine kinase receptor in human cancer.

Authors: M Jeffers; L Schmidt; N Nakaigawa; C P Webb; G Weirich; T Kishida; B Zbar; G F Vande Woude
Journal: Proc Natl Acad Sci U S A Date: 1997-10-14 Impact factor: 11.205

6. The HGF receptor c-Met is overexpressed in esophageal adenocarcinoma.

Authors: Luis J Herrera; Talal El-Hefnawy; Pierre E Queiroz de Oliveira; Siva Raja; Sydney Finkelstein; William Gooding; James D Luketich; Tony E Godfrey; Steven J Hughes
Journal: Neoplasia Date: 2005-01 Impact factor: 5.715

7. Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase.

Authors: Christine A Parachoniak; Morag Park
Journal: J Biol Chem Date: 2008-12-24 Impact factor: 5.157

8. Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues.

Authors: Yun-Quan Luo; Meng-Chao Wu; Wen-Ming Cong
Journal: World J Gastroenterol Date: 1999-04 Impact factor: 5.742

Review 9. Circulating tumor cells and CDX models as a tool for preclinical drug development.

Authors: Alice Lallo; Maximilian W Schenk; Kristopher K Frese; Fiona Blackhall; Caroline Dive
Journal: Transl Lung Cancer Res Date: 2017-08

10. Suppression of the progress of disseminated pancreatic cancer cells by NK4 plasmid DNA released from cationized gelatin microspheres.

Authors: Toshihiro Kushibiki; Kunio Matsumoto; Toshikazu Nakamura; Yasuhiko Tabata
Journal: Pharm Res Date: 2004-07 Impact factor: 4.200