| Literature DB >> 3470599 |
M A Tainsky, F L Shamanski, D Blair, G Vande Woude.
Abstract
We used human oncogene DNA to transform the nontumorigenic, revertant, human osteosarcoma cell line HOS TE-85 clone 5 (ATCC CRL 1543) to tumorigenicity in athymic nude mice with latency periods as short as 3 weeks. These cells were also transformed by genetic markers in genomic DNA samples. Because of their low rate of spontaneous tumor formation and the simplicity of culturing them, HOS cells provide a human cell alternative to NIH 3T3 murine fibroblasts for oncogene transfection studies.Entities:
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Year: 1987 PMID: 3470599 PMCID: PMC365204 DOI: 10.1128/mcb.7.3.1280-1284.1987
Source DB: PubMed Journal: Mol Cell Biol ISSN: 0270-7306 Impact factor: 4.272